Evolutionary Mechanisms of Defense Reactions

  • Václav Větvička
  • Petr Šíma

Part of the Advances in Life Sciences book series (ALS)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Václav Větvička, Petr Šíma
    Pages 1-8
  3. Václav Větvička, Petr Šíma
    Pages 9-17
  4. Václav Větvička, Petr Šíma
    Pages 19-25
  5. Václav Větvička, Petr Šíma
    Pages 27-86
  6. Václav Větvička, Petr Šíma
    Pages 87-185
  7. Václav Větvička, Petr Šíma
    Pages 187-189
  8. Back Matter
    Pages 191-201

About this book


At present, we do not fully understand at what stage of the evolution of living matter the first traces of defense reactions occurred. We even do not fully understand how and why immune systems reached their contem­ porary state in advanced vertebrates and man. It may be expected that in the near future these questions will be answered by comparative and develop­ mental biology. Together with an extraordinary explosion of our knowledge about immunity of mammals including man, an increase in the interests concerning origin and development of immune mechanisms at lower stages of the phylogeny can be observed. The search for simple types of immune mechanisms in less complex but still evolutionary successful animals is promising and may contribute to better understanding of highly complex immune adaptive responses in mammals. It is important to note that comparative and evolutionary immunology differs greatly from other branches of biomedical science. Apart from immunology and molecular biology, a specialist in this discipline has to be familiar with every detail of taxonomy, comparative anatomy, physiology, embryology, and even with the phyletic relationships of animals. Probably no monography could deal with the entire animal kingdom, because, in many cases, the insights into questions about immune mecha­ nisms of many animal groupings or phyla, and their possible evolutionary implications, are unknown or just now beginning to take shape. For the moment, our knowledge on such matters relies upon reconstructions of ideas that we have deduced from studies on members of relative taxa.


biology defense mechanism development evolution evolutionary biology immune system immunology pathology

Authors and affiliations

  • Václav Větvička
    • 1
  • Petr Šíma
    • 2
  1. 1.Dept. of Pathology School of Medicine Div. of Experimental Immunology and ImmunopathologyUniversity of LouisvilleLouisvilleUSA
  2. 2.Dept. of Immunology Institute of MicrobiologyAcademy of Science of the Czech RepublicPragueCzech Republic

Bibliographic information