Nitric Oxide in Pulmonary Processes

Role in Physiology and Pathophysiology of Lung Disease

  • Maria G. Belvisi
  • Jane A. Mitchell

Part of the Respiratory Pharmacology and Pharmacotherapy book series (RPP)

Table of contents

  1. Front Matter
    Pages I-IX
  2. Introduction to Nitric Oxide Biology

    1. Front Matter
      Pages 1-1
    2. David Bishop-Bailey, Jane A. Mitchell
      Pages 3-20
    3. Gregory J. Quinlan, Nicholas J. Lamb
      Pages 21-38
  3. Role of Endogenous Nitric Oxide in the Lung

    1. Front Matter
      Pages 39-39
    2. Shu F. Liu, Timothy W. Evans
      Pages 89-110
    3. Frans P. Nijkamp, Gert Folkerts
      Pages 111-126
    4. Sanjay Mehta, Jeffrey M. Drazen
      Pages 127-149
    5. El-Bdaoui Haddad
      Pages 151-164
  4. Therapeutic Potential of Inhaled Nitric Oxide and Nitric Oxide Synthase Inhibitors in Lung Disease

    1. Front Matter
      Pages 165-165
    2. Peter J. Barnes, Sergei A. Kharitonov
      Pages 167-183
    3. Kjell Alving, Jon O. N. Lundberg, Johan Rinder, Eddie Weitzberg
      Pages 185-199
    4. Helen M. Marriott, Timothy W. Higenbottam
      Pages 201-208
  5. Back Matter
    Pages 227-230

About this book


Nitric oxide is an endogenously produced gas with a wide range of biological effects and has been implicated in many physiological and pathophysiological processes. It is released by many cell types in various organs but is particularly important in the maintenance of normal lung function. Nitric oxide in exhaled breath has been identified as a marker for lung disease in some patients. Thus, it is appropriate to consider the lung separately for the role and functioning of nitric oxide. The authors identify key areas in the history, biochemistry, physiology, pathophysiology, immunology and clinical applications of nitric oxide in the lung. The contents of this book will be of particular importance to scientists and clinicians with an interest in lung disease. Moreover, the authors encompass state of the art opinions of and rational for the therapeutic potential of nitric oxide and its inhibitors.


Respiratory research biochemistry cell chemistry immunology nitric oxide pathophysiology pharmacology physiology research

Editors and affiliations

  • Maria G. Belvisi
    • 1
  • Jane A. Mitchell
    • 2
  1. 1.Pharmacology DepartmentRhône-Poulenc Rorer Research & DevelopmentDagenham, EssexUK
  2. 2.Unit of Critical Care Medicine Imperial College Medical SchoolRoyal Brompton HospitalLondonUK

Bibliographic information