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Inflammatory Processes:

Molecular Mechanisms and Therapeutic Opportunities

  • L. Gordon Letts
  • Douglas W. Morgan
Conference proceedings

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xi
  2. The role of eotaxin and related CC-chemokines in asthma and allergy

    1. Tracey J. Mitchell, Timothy J. Williams
      Pages 1-12
  3. Signal transduction by the JNK group of MAP kinases

  4. Cellular signaling to NF-кB: Role in inflammation and therapeutic promise

  5. Small molecule regulators of AP-1 and NF-кB

    1. Anthony M. Manning
      Pages 39-51
  6. Mammalian target of rapamycin: Immunosuppressive drugs offer new insights into cell growth regulation

  7. Constitutive expression of a tumor suppressor leads to tumor regression in a xenograft model

    1. Catherine Adams Burton, John Boylan, Candy Robinson, Janet Kerr, Pamela Benfield
      Pages 67-76
  8. Macrophage metalloproteinases in destructive inflammatory diseases

  9. Lymphotoxin in inflammation and lymphoid organ development: Variations on a theme

  10. Chemokine/cytokine biology during the evolution of fibrotic disease

    1. Steven L. Kunkel, Sem H. Phan, Nicholas W. Lukacs, Cory Hogaboam, Stephen W. Chensue
      Pages 89-98
  11. The role of MCP-1 in disease

    1. Long Gu, Susan C. Tseng, Barrett J. Rollins
      Pages 99-107
  12. The role of chemokines in allergic diseases of the airways

    1. Lisa A. Beck, Cristiana Stellato, Syed Shahabuddin, Renate Nickel, Robert P. Schleimer
      Pages 109-118
  13. Ninth International Conference of the Inflammation Research Association, November 1-5, 1998: Summaries of workshops and poster discussions

    1. Front Matter
      Pages 119-119
    2. Willam Williams, Elizabeth Arner
      Pages 121-123
    3. Lawrence Wennogle, Nancy Cusack
      Pages 125-128
    4. James Burke, Floyd Chilton
      Pages 129-130
    5. Denis Schrier, Fandrew Issekutz
      Pages 131-133
    6. Robert M. Strieter, David Underwood
      Pages 135-137
    7. W. Hunter, E. Turley
      Pages 139-140
  14. Back Matter
    Pages 141-144

About these proceedings

Introduction

In November 1998 many of the key leaders of new drug discovery for inflammatory diseases gathered at Hershey, Pennsylvania for the 9th International Conference of the Inflammation Research Association. The Conference was held over a five day period and provided a stimulating environment for the open exchange of important advances in basic inflammation research as well as new drug discovery and development. This book encompasses some of the highlights of several presentations made at the Conference. It contains some of the latest and important developments in the field of inflammation research. Topics include the status of eotaxin and chemokines in asthma and allergy, signal transduction and regulation of diverse mediators such as the JNK group of MAP kinases, TNF and IL-1 signaling of NF-kB as well as regulators of AP-1, macrophage metalloproteinases, lymphotoxin and further insights into the role of MCP-1 in disease. Also discussed are drug targets in rheumatoid and osteoarthritis, fibrotic diseases,...

Keywords

Chemokine asthma gene expression molecular mechanisms regulation signal transduction

Editors and affiliations

  • L. Gordon Letts
    • 1
  • Douglas W. Morgan
    • 2
  1. 1.NitroMed Inc.BedfordUSA
  2. 2.Abbott LaboratoriesAbbott ParkUSA

Bibliographic information