The Carbonic Anhydrases

New Horizons

  • W. Richard Chegwidden
  • Nicholas D. Carter
  • Yvonne H. Edwards

Part of the EXS 90 book series (EXS, volume 90)

Table of contents

  1. Front Matter
    Pages I-XVIII
  2. Exordium: Remarks on the discovery of carbonic anhydrase

    1. Robert E. Forster
      Pages 1-11
    2. W. Richard Chegwidden, Nicholas D. Carter
      Pages 13-28
  3. Carbonic Anhydrase Isoforms and their Expression in Mammals

    1. Front Matter
      Pages 77-77
    2. Richard E. Tashian, David Hewett-Emmett, Nick Carter, Nils C. H. Bergenhem
      Pages 105-120
    3. Yvonne Edwards, Felicity Drummond, Jane Sowden
      Pages 121-141
    4. Yvonne Ridderstråle, Per J. Wistrand, Lena Holm, Nicholas D. Carter
      Pages 143-155
  4. Structure and Mechanism

    1. Front Matter
      Pages 157-157
    2. Travis Stams, David W. Christianson
      Pages 159-174
    3. Sven Lindskog, David N. Silverman
      Pages 175-195
    4. Claudiu T. Supuran, Andrea Scozzafava
      Pages 197-219
    5. Jennifer A. Hunt, Charles A. Lesburg, David W. Christianson, Richard B. Thompson, Carol A. Fierke
      Pages 221-240
    6. Uno Carlsson, Bengt-Harald Jonsson
      Pages 241-259
  5. Physiology

    1. Front Matter
      Pages 261-261
    2. W. Richard Chegwidden, Susanna J. Dodgson, Ian M. Spencer
      Pages 343-363
    3. Petra Wetzel, Gerolf Gros
      Pages 375-399
  6. Clinically Related Studies

    1. Front Matter
      Pages 401-401
    2. Umar F. Mansoor, Xiu-Rong Zhang, G. Michael Blackburn
      Pages 437-459
    3. Wendy B. Cammer, Luc P. Brion
      Pages 475-489
    4. Teuvo A. Hentunen, Pirkko L. Härkönen, H. Kalervo Väänänen
      Pages 491-497
  7. Plant, Algal and Bacterial Carbonic Anhydrases

    1. Front Matter
      Pages 499-499
    2. Hideya Fukuzawa, Mikio Tsuzuki, Shigetoh Miyachi
      Pages 535-546
    3. Evguenii I. Kozliak, Michel B. Guilloton, James A. Fuchs, Paul M. Anderson
      Pages 547-565
  8. Postscriptum

    1. Front Matter
      Pages 567-567
    2. Richard E. Tashian
      Pages 569-596
  9. Back Matter
    Pages 611-619

About this book


Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene target studies. Since the early use of CA inhibitors as diuretics and in treating congestive heart failure, the enzyme has been target of considerable clinical attention. Much of this is now focused on endeavours to produce a new generation of such drugs for the effective treatment of glaucoma and other potential applications. Recent data, suggesting links between CA and various disease processes, including cancer, have stimulated further...


Resorption biochemistry bone carbon enzyme enzymes evolution membrane transport metabolism photosynthesis physiology protein protein folding respiration synthesis

Editors and affiliations

  • W. Richard Chegwidden
    • 1
  • Nicholas D. Carter
    • 2
  • Yvonne H. Edwards
    • 3
  1. 1.Lake Erie College of Osteopathic MedicineErieUSA
  2. 2.Medical Genetics UnitSt George’s Hospital Medical SchoolLondonUK
  3. 3.MRC Human Biochemical Genetics Unit, Wolfson HouseUniversity College LondonLondonUK

Bibliographic information

  • DOI
  • Copyright Information Birkhäuser Verlag 2000
  • Publisher Name Birkhäuser, Basel
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-0348-9570-5
  • Online ISBN 978-3-0348-8446-4
  • Series Print ISSN 1023-294X
  • Buy this book on publisher's site