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Macrolide Antibiotics

  • Wolfgang Schönfeld
  • Herbert A. Kirst

Part of the Milestones in Drug Therapy MDT book series (MDT)

Table of contents

  1. Front Matter
    Pages I-X
  2. Herbert A. Kirst
    Pages 1-13
  3. Vito R. Iacoviello, Stephen H. Zinner
    Pages 15-24
  4. Holly M. Mattoes, Charles H. Nightingale
    Pages 25-36
  5. Takashi Adachi, Shigeo Morimoto
    Pages 53-72
  6. Wolfgang Schönfeld, Stjepan Mutak
    Pages 73-95
  7. Leonard Katz
    Pages 157-175
  8. Adel Ben Ali, Fred W. Goldstein, Jacques F. Acar
    Pages 185-200
  9. Lowell S. Young, Luiz E. Bermudez
    Pages 201-213
  10. Francis Mégraud
    Pages 243-260
  11. Joyce A Sutcliffe, Roland Leclercq
    Pages 281-317
  12. Back Matter
    Pages 319-323

About this book

Introduction

The current state of research, development, and use of macrolides as a treatment option for bacterial infections is the subject of this monograph. Macrolides, whose first representative (erythromycin) was introduced into the market in the 1950s, have been optimised by various companies into effective, safe, and convenient treatments with overwhelming success. Various compounds, such as azithromycin, clarithromycin, erythromycin, and roxithromycin, are in current effective use for treatment of infections mainly of the respiratory, gastrointestinal, and urogenital tracts and skin and soft tissues. A highly competitive research environment and critical medical need for improved macrolides have led to various new scaffolds and derivatives such as the ketolides ABT-773 and telithromycin, which are in development or in the regulatory process for market approval.

The individual chapters cover aspects of microbiology, clinical use and experience, pharmacokinetics, pharmacodynamics, biochemistry, and chemistry. They are written by leading experts in their respective fields. Thus, readers - whether they are professionals in the pharmaceutical industry, physicians treating infections, or biochemists, chemists, pharmacologists or microbiologists at hospitals, health institutes, or universities - will find a detailed and up-to-date knowledge base about current research activities and a sound, stimulating overview of the compound class.

Keywords

Antibiotika Infektionskrankheiten Sexually Transmitted Diseases antibiotics asthma bacteria bacterial infection bacterial infections infection infections infectious disease tissue

Editors and affiliations

  • Wolfgang Schönfeld
    • 1
  • Herbert A. Kirst
    • 2
  1. 1.PLIVA Research Antiinfective ResearchZagrebCroatia
  2. 2.Elanco Animal Health Research & DevelopmentGreenfieldUSA

Bibliographic information