Heat Shock Proteins and Inflammation

  • Willem van Eden

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Irun R. Cohen, Francisco J. Quintana, Gabriel Nussbaum, Michal Cohen, Alexandra ZaninZhorov, Ofer Lider
    Pages 1-13
  3. Willem van Eden, Liesbeth Paul, Ruurd van der Zee
    Pages 15-31
  4. Sreyashi Basu, Pramod Srivastava
    Pages 33-42
  5. Clarissa U. I. Prazeres da Costa, Hermann Wagner, Thomas C. Miethke
    Pages 43-54
  6. Arne van Bonin, Minka Breloer, Solveig H. Moré
    Pages 55-67
  7. Rebecca J. Brownlie, Stephen J. Thompson
    Pages 69-82
  8. J. S. Hill Gaston, Richard C. Duggleby, Jane C. Goodall, Roberto Raggiaschi, Mark S. Lillicrap
    Pages 83-96
  9. Ismé M. de Kleer, Berent P. Prakken, Salvatore Albani, Wietse Kuis
    Pages 97-108
  10. Gabriel S. Panayi, Valerie M. Corrigall
    Pages 109-137
  11. Gisella L. Puga Yung, Tho D. Le, Sarah Roord, Berent Prakken, Salvatore Albani
    Pages 139-158
  12. Michael Knoflach, Bruno Mayrl, Mahavir Singh, Georg Wick
    Pages 159-173
  13. Kalle Söderström
    Pages 257-272
  14. Back Matter
    Pages 273-280

About this book


Heat shock proteins have received ample interest by immunologists over recent years. Initially they were found to be dominantly immunogenic microbial antigens. The connection to inflammation was established when it was uncovered that T cells reactive to hsp60 of mycobacteria had a crucial role in the induction and, more interestingly, regulation of experimental arthritis. Since then, the raised presence of immunity to hsp in virtually all conditions of inflammation, including autoimmune diseases, transplant rejection and atherosclerosis, has emphasised the critical significance of immunity to hsp in inflammatory diseases. Recently, first trials with hsp peptides were undertaken and reported in type I diabetes and in arthritis. As this has stimulated a wide interest in this particular field the book aims at giving an update of these exciting current developments and to provide the basis for understanding the mode of action of hsp based immunotherapeutic interventions.  This will include aspects of specific adaptive immunity and aspects of innate immunity.

The book has its focus on immunity to hsp and its impact on the regulation of inflammation. It is of interest to biologists, immunologists, microbiologists and other researchers, but also clinicians interested in the rapidly evolving field of immune-interventions.


Activation Arthritis bacteria diseases immune response immune system immunity immunotherapy inflammation influence kidney mycobacteria proteins regulation rheumatoid arthritis

Editors and affiliations

  • Willem van Eden
    • 1
  1. 1.Division of Immunology, Department of Infectious Diseases and ImmunologyFaculty of Veterinary Medicine, University of UtrechtUtrechtThe Netherlands

Bibliographic information