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Hepatitis Prevention and Treatment

  • Joseph M. Colacino
  • Beverly A. Heinz

Part of the Milestones in Drug Therapy book series (MDT)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Gururaj Kalkeri, Ann D. Kwong
    Pages 1-27
  3. Lynn D. Condreay, Sarah A. Harris
    Pages 39-65
  4. Guangxiang Luo
    Pages 67-85
  5. Tomasz I. Michalak
    Pages 87-105
  6. Eleanor J. Barnes, Nasser Semmo, Paul Klenerman
    Pages 107-123
  7. Nathaniel A. Brown, Richard E. Boehme
    Pages 125-140
  8. Anouk Dev, Keyur Patel, John G. Mc Hutchison
    Pages 141-156
  9. Craig S. Gibbs
    Pages 157-173
  10. Tim Shaw, Stephen Locarnini
    Pages 203-238
  11. Back Matter
    Pages 239-246

About this book

Introduction

Chronic viral hepatitis has emerged as one of the most common causes of disease and death worldwide. Because of their unique modes of replication and intimate association with the host immune system, hepatitis B virus (HBV) and hepatitis C virus (HCV) pose challenging problems to scientists in basic and applied research as well as to clinicians engaged in disease management. Although approved antiviral therapy is available for chronic HBV, the emergence of viral resistance provides a rationale for the development of novel chemotherapeutic agents. The lack of a robust cell culture system for HCV replication and a readily accessible small-animal model of HCV infection have hampered the development of antiviral agents for HCV. Neverthe-less, new antiviral agents targeting HCV are now in preclinical and clinical development.

This monograph, providing an up-to-date overview of the field of Hepatitis Prevention and Treatment, includes contributions from internationally recognized experts in the field of viral hepatitis, and covers the current state of knowledge and practice regarding the molecular biology, immunology, biochemistry, pharmacology and clinical aspects of chronic HBV and HCV infection. The volume includes salient topics such as: the history and epidemiology of HBV and HCV; recent insights into the molecular mechanisms of viral replication; the host immune response to infection and a discussion of the use (HBV) or potential development (HCV) of vaccines; the current standard of care for chronically-infected patients; and emerging therapies and issues associated with current antiviral treatments. The latest information to researchers and clinicians actively engaged in viral hepatitis research is provided, but also sufficient background and discussion of the literature to benefit the newcomer to the field.

Keywords

Epidemiology Hepatitis Hepatitis B Virus Hepatitis C Virus Molecular Virology New therapeutical approaches Therapy Viral Immunology infection virology virus

Editors and affiliations

  • Joseph M. Colacino
    • 1
  • Beverly A. Heinz
    • 2
  1. 1.PTC TherapeuticsDrug DiscoverySouth PlainfieldUSA
  2. 2.Eli Lilly and CompanyDiscovery ResearchIndianapolisUSA

Bibliographic information