Cytokines and Joint Injury

  • Wim B. van den Berg
  • Pierre Miossec

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Cem Gabay
    Pages 69-87
  3. Norihiro Nishimoto, Tadamitsu Kishimoto
    Pages 89-106
  4. J. Alastair Gracie, Sarah L. Jongbloed, Hilary Wilson, Iain B. McInnes
    Pages 127-145
  5. Danielle Burger, Pascale Roux-Lombard, Carlo Chizzolini, Jean-Michel Dayer
    Pages 165-188
  6. Tim E. Cawston, Andrew D. Rowan
    Pages 189-220
  7. Brad Bolon, Victoria Shalhoub, Paul J. Kostenuik, Debra Zack, Ulrich Feige
    Pages 221-267
  8. Erik Lubberts, Wim B. van den Berg
    Pages 269-289
  9. Back Matter
    Pages 291-298

About this book


The purpose of this volume in the Progress in Inflammation Research series is to provide the biomedical and clinical researcher with a state-of-the-art insight in the role of cytokines in joint inflammation and joint destruction. This is of relevance for better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of old and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Spe­ cial attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage destruction and bone erosion. In addition to an outline of the role of established cytokines, such as TNF, IL-l and IL-6, new information is given on the novel cytokines IL-15, IL-17 and IL-18 and their positioning in the complex cytokine interplay. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles as central players in joint erosion are highlighted. Together, the chapters provide a complete and balanced view on pivotal cytokines and joint pathology.


Arthritis bone cytokine cytokines diseases inflammation joint necrosis osteoarthritis pathology protein regulation research rheumatoid arthritis tissue

Editors and affiliations

  • Wim B. van den Berg
    • 1
  • Pierre Miossec
    • 2
  1. 1.Rheumatology Research LabUniversity Medical Center Nijmegen, 189NijmegenThe Netherlands
  2. 2.Hôpital Edouard Herriot Service de Rhumatologie Unité d’Immunologie CliniqueUniversité Claude Bernard — Lyon 1LyonFrance

Bibliographic information