Bone Morphogenetic Proteins: Regeneration of Bone and Beyond

  • Slobodan Vukicevic
  • Kuber T. Sampath

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Olexander Korchynskyi, Rutger L. van Bezooijen, Clemens W. G. M. Löwik, Peter ten Dijke
    Pages 9-44
  3. Snjezana Martinovic, Petra Simic, Fran Borovecki, Slobodan Vukicevic
    Pages 45-72
  4. Petra Simic, Slobodan Vukicevic
    Pages 73-108
  5. David C. Rueger, Susan Chubinskaya
    Pages 109-132
  6. Hendrik Terheyden, Søren Jepsen
    Pages 133-155
  7. Frank P. Luyten, Rik Lories, Dirk De Valck, Cosimo De Bari, Francesco Dell’Accio
    Pages 187-212
  8. Fran Borovecki, Petra Simic, Lovorka Grgurevic, Slobodan Vukicevic
    Pages 213-243
  9. Pamela Lein, Dennis Higgins
    Pages 245-266
  10. Joachim H. Clement, Stefan Wölfl
    Pages 267-292
  11. Vishwas M. Paralkar, William A. Grasser, Keith A. Riccardi, David D. Thompson, Slobodan Vukicevic
    Pages 293-305
  12. Back Matter
    Pages 305-312

About this book


Since the discovery of the bone morphogenetic proteins (BMPs) more than 15 years ago, there has been an unpredicted explosion of both basic scientific discoveries and clinical reports on their use from institutions all over the world. The potent effica­ cy of BMPs in almost all crucial developmental events as well as during regenera­ tion of various organs such as bone, kidney, brain, liver, heart etc. , has positioned BMPs at the center of scientific interest. Many of these aspects are covered in this new PIR volume. Their role in development, biology, signal transduction, kidney regeneration, eNS functions, craniofacial skeleton reconstruction, joint and carti­ lage repair, long bone non-unions and acute fractures, and spinal fusion is reviewed by experts in the field. For the first time, the role of BMPs in carcinogenesis has been reviewed to provide a rationale for applying their biology in patients with bone tumors. The optimism resulting from safe and successful treatment with BMPs for various skeletal malformations of more than 10,000 patients worldwide has opened new avenues for exploring other indications for their use. The next big challenge for bringing BMPs to the benefit ofmankind is in regenerating articular cartilage defects and rescuing patients with acute and chronic renal failure. The volume editors thank all authors for the rapid preparation of their chapters in order that the book remains up-to-date for readers with specific interest in the field of regenerative medicine. The important contribution of Mrs. Morana and Mr.


biology bone cancer cartilage development diseases kidney nephrology oncology prostate cancer protein proteins regeneration regenerative medicine tissue

Editors and affiliations

  • Slobodan Vukicevic
    • 1
  • Kuber T. Sampath
    • 2
  1. 1.Laboratory for Mineralized TissuesSchool of MedicineZagrebCroatia
  2. 2.Genzyme CorporationFraminghamUSA

Bibliographic information