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Airways Smooth Muscle: Development, and Regulation of Contractility

  • David Raeburn
  • Mark A. Giembycz

Part of the Respiratory Pharmacology and Pharmacotherapy book series (RPP)

Table of contents

  1. Front Matter
    Pages I-VIII
  2. Reynold A. Panettieri Jr.
    Pages 41-68
  3. Newman L. Stephens, He Jiang, Weilong Li, Chun Y. Seow
    Pages 69-100
  4. Roger C. Small, Robert W. Foster
    Pages 137-161
  5. Tadao Tomita, Hiroaki Kume
    Pages 163-184
  6. Magdalena Souhrada, Joseph F. Souhrada
    Pages 219-258
  7. David Raeburn, Frank R. Goodman
    Pages 291-305
  8. Karen E. Pedersen, Roy G. Goldie
    Pages 307-373
  9. Back Matter
    Pages 411-423

About this book

Introduction

Most studies on autonomic innervation of smooth muscle have focused on the short-term mechanisms involved in neurotransmission in physiological and pathophysiological conditions. However recent obser­ vations of the long-term plasticity of this system, i. e. its capacity for regeneration and for compensatory change in pattern of innervation and expression of cotransmitters and receptors in ageing, following surgery, trauma or in disease, have indicated that an understanding of the mechanisms involved could influence the design of therapeutic regimes. There is increasing evidence for long-term communication between nerves and smooth muscle cells during development and throughout adult life. To date, the trophic interactions between nerves and airway musculature have attracted little interest, consequently, much of the information presented here is drawn from studies using other smooth muscles. However, the questions posed about trophic interactions dur­ ing development apply as much to airways smooth muscle neuroeffector systems as to other autonomic neuroeffector systems. These are: i) How do developing nerve fibres know where to go and how do they reach their target sites? ii) What determines the density and pattern of inner­ vation at reaching the effector? iii) How do the nerves survive and maintain their position once established? iv) What factors influence neurochemical differentiation such that genetically multipotential neu­ rones are triggered to synthesize one or combinations of neurotransmit­ ters? v) What influence do nerves have on the structure, function and receptor expression of their effector cells? vi) How do diseases interrupt these processes? - see [1].

Keywords

Airways Physiologie Physiology cells glatte Muskulatur der Atemwege smooth muscle surgery

Editors and affiliations

  • David Raeburn
    • 1
  • Mark A. Giembycz
    • 2
  1. 1.Discovery Biology, Rhône-Poulenc Rorer LtdDagenham Research CentreDagenham, EssexEngland
  2. 2.Department of Thoracic MedicineRoyal Brompton National Heart and Lung InstituteLondonEngland

Bibliographic information