Nonselective Cation Channels

Pharmacology, Physiology and Biophysics

  • Detlef Siemen
  • Jürgen Hescheler

Part of the EXS book series (EXS, volume 66)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Detlef Siemen
      Pages 3-25
  3. Receptor-Activated Nonselective Cation Channels

  4. Mechanically Sensitive Cation Channels

  5. Gap Junction Channels

    1. Front Matter
      Pages 107-107
    2. Rolf Dermietzel
      Pages 109-117
  6. Cyclic Nucleotide-Activated Nonselective Cation Channels

  7. Channels Activated by Intracellular Calcium

    1. Front Matter
      Pages 173-173
    2. Peter Thorn, Ole H. Petersen
      Pages 185-200
    3. Ari Koivisto, Elisabeth Dotzler, Ulrich Ruß, Jan Nedergaard, Detlef Siemen
      Pages 201-211
    4. R. Popp, H. C. Englert, H. J. Lang, H. Gögelein
      Pages 213-218
    5. Christiane Siemer, Heinz Gögelein
      Pages 219-222
  8. Nonselective Cation Channels as Regulatory Components of Cells from Various Tissues

  9. Back Matter
    Pages 311-320

About this book


It can be argued that nonselective cation channels were the first sort of ion channel to be described, though the word channel was not used at the time. Their existence was implied by Fatt and Katz in 1952, when they described the action of acetylcholine at the muscle endplate as producing "a large nonselective increase of ion permeability, i.e. a short circuit". Shortly afterwards, in 1956, Katz referred to "aqueous channels through which small ions can pass ... " (del Castillo and Katz, Prog. Biophysics and Biophys. Chern. 6, 121-170). Now, more than thirty years later, it has become clear that there are far more types of nonselective cation channels than anyone could have imagined a few years ago, and that they are found in a vast range of tissues. One has, of course, become quite accustomed to such diversity in, for example, GABA receptors, but this is not quite the same thing. A In the case of GABAA receptor we are talking about a fairly narrow range of structural diversity (resulting largely from differences in subunit composition) within a single type of channel with more-or-Iess well­ defined function. In the case of nonselective cation channels the function is often not known, and relatively few have been cloned. It seems certain though, that they encompass a wide range of quite different structural types.


GABA biophysics muscle physiology research tissue

Editors and affiliations

  • Detlef Siemen
    • 1
  • Jürgen Hescheler
    • 2
  1. 1.Institut für ZoologieUniversität RegensburgRegensburgGermany
  2. 2.Institut für PharmakologieFreie Universität BerlinBerlinGermany

Bibliographic information

  • DOI
  • Copyright Information Birkhäuser Basel 1993
  • Publisher Name Birkhäuser Basel
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-0348-7329-1
  • Online ISBN 978-3-0348-7327-7
  • Series Print ISSN 1023-294X
  • Buy this book on publisher's site