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The Steroid/Thyroid Hormone Receptor Family and Gene Regulation

Proceedings of the 2nd International CBT Symposium Stockholm, Sweden, November 4–5, 1988

  • Jan Carlstedt-Duke
  • Håkan Eriksson
  • Jan-Åke Gustafsson

Part of the Birkhäuser Congress Reports Life Sciences book series (ALS)

Table of contents

  1. Front Matter
    Pages 1-10
  2. Receptor Structure

    1. Bert W. O’Malley, S. Y. Tsai, M.-J. Tsai, O. M. Conneely, W. T. Schrader
      Pages 29-40
    2. Ann-Charlotte Wikström, Marc Denis, Gunnar Akner, Oddmund Bakke, Jan- Åke Gustafsson
      Pages 41-53
    3. H. Gronemeyer, V. Kumar, S. Green, M. T. Bocquel, L. Tora, M. E. Meyer et al.
      Pages 55-67
    4. T. N. Lavin, M. F. Norman, N. Eberhardt, J. D. Baxter
      Pages 69-81
    5. S. Liao, C. Chang, J. Kokontis, T. Popovich, R. A. Hiipakka
      Pages 83-92
    6. Jan Carlstedt-Duke, Per-Erik Strömstedt, Karin Dahlman, Carol Rae, Anders Berkenstam, Janet Hapgood et al.
      Pages 93-108
    7. W. B. Pratt, T. Redmond, E. R. Sanchez, E. H. Bresnick, S. Meshinchi, M. J. Welsh
      Pages 109-126
    8. E. Brad Thompson, Y-S. Yuh, D. Harbour, J. Ashraf, B. Johnson, J. M. Harmon
      Pages 127-145
    9. J. W. Pike, D. P. McDonnell, R. A. Scott, S. A. Kerner, R. A. Kesterson, B. W. O’Malley
      Pages 147-159
    10. Björn Vennström, Jan Sap, Jackie Schmitt, Douglas Forrest, Alberto Muñoz, Martin Zenke et al.
      Pages 161-168
    11. P. W. Faber, G. G. J. M. Kuiper, H. C. J. van Rooij, J. A. G. M. van der Korput, A. O. Brinkmann, J. Trapman
      Pages 169-181
    12. Chawnshang Chang, Lester Lau, Shutsung Liao, John Kokontis
      Pages 183-193
  3. Gene Regulation by Receptors

    1. D. Granner, D. Chu, C. Davis, N. Chrapkiewicz
      Pages 195-206
    2. T. K. Archer, M. G. Cordingley, V. Marsaud, H. Richard-Foy, G. L. Hager
      Pages 221-238
    3. Deborah A. Bravo, Emily J. Platt, Laurie J. Goodman, Gary L. Firestone
      Pages 239-252
  4. Receptor Localisation and Distribution

    1. Bruce S. McEwen, Hector Coirini, Maya Frankfurt, John Gerlach, Allan Johnson, Michael Schumacher
      Pages 263-270
    2. A. Bailly, A. Guiochon-Mantel, M. Misrahi, H. Loosfelt, M. Atger, J. F. Savouret et al.
      Pages 271-279
    3. Robert M. Brenner, Neal B. West, Maryanne C. McClellan, Sheri A. Hild-Petito, Richard L. Stouffer
      Pages 281-300
    4. E. E. Baulieu, N. Binart, F. Cadepond, M. G. Catelli, B. Chambraud, J. Garnier et al.
      Pages 301-318
  5. Ligand Structure

    1. J. P. Reynaud, V. Bissery, C. Gaboriaud, T. Ojasoo, G. Teutsch, J. P. Mornon
      Pages 337-366
  6. Back Matter
    Pages 367-371

About this book

Introduction

The Second International CBT (Center for Biotechnology) Synposium was held in Stockholm November 4-5 1988 and had the title "The steroid/thyroid hoITIDne receptor family and gene regulation". This meeting contained contributions from most leading laboratories within the field of steroid/thyroid hOITIDne receptors and gave a very exciting perspective on the dynamic development of this i:ntx>rt. ant research field. Today all known steroid hoITIDne receptors have been cloned and sequenced and novel members of this supergene family are constantly being discovered. Sane of these new receptors remain to be characterized regarding the nature of their ligand. Access to probes for steroid receptors has enabled studies on mechanisms of regulation of receptor gene expression. Deletion and II'Altational analysis of steroid receptor cDNAs followed by expression in cells together with suitable reporter genes has yielded a detailed knowledge about the functional significance of the various domains the receptors are composed of. In certain cases, steroid resistance in patients have been shown to be due to point mutations in the corresponding steroid receptor genes resulting in non-functional receptors. The availability of receptor cDNAs also makes it possible to express receptors at high levels in procaryotic and eucaryotic cells. It is e. g. possible to express the DNA-binding domain of the glucocorticoid receptor in E. coli as a fusion protein with protein A which interacts specifically with DNA. Such studies are necessary for production of sufficient quantities of receptors to allow crystallization and X-ray crystallography for detailed structural information.

Keywords

chromosome DNA gene expression genes mutation Promoter protein proteins receptor transcription Vitamin D

Editors and affiliations

  • Jan Carlstedt-Duke
    • 1
  • Håkan Eriksson
    • 2
  • Jan-Åke Gustafsson
    • 1
  1. 1.Dept. of Medical Nutrition, Karolinska InstituteHuddinge University Hospital F69HuddingeSweden
  2. 2.Reproductive Endocrinology, Research UnitKarolinska HospitalStockholmSweden

Bibliographic information