Gamma-Glutamyl Transpeptidases

Structure and Function

  • Immacolata Castellano
  • Antonello Merlino

Part of the SpringerBriefs in Biochemistry and Molecular Biology book series (BRIEFSBIOCHEM)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Immacolata Castellano, Antonello Merlino
    Pages 1-57

About this book


 Gamma-Glutamyl Transpeptidases (γ-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the γ-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released γ-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). γ-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.γ-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson’s disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of γ-GTs and gives information about applications of γ-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.​


Cellular redox homeostasis Enzymes Glutathione metabolism Inflammation Oxidative stress Transferases

Authors and affiliations

  • Immacolata Castellano
    • 1
  • Antonello Merlino
    • 2
  1. 1.SZNStazione Zoologica Anton DohrnNaplesItaly
  2. 2., Dep. of Chemical SciencesUniversity of NaplesNaplesItaly

Bibliographic information

  • DOI
  • Copyright Information The Author(s) 2013
  • Publisher Name Springer, Basel
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-0348-0681-7
  • Online ISBN 978-3-0348-0682-4
  • Series Print ISSN 2211-9353
  • Series Online ISSN 2211-9361
  • About this book