© 2013

Untranslated Gene Regions and Other Non-coding Elements

Regulation of Eukaryotic Gene Expression


Part of the SpringerBriefs in Biochemistry and Molecular Biology book series (BRIEFSBIOCHEM)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Lucy W. Barrett, Sue Fletcher, Steve D. Wilton
    Pages 1-56

About this book


There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.​


DNA regulation Gene expression Introns Junk DNA Non-coding RNA Promotors

Authors and affiliations

  1. 1.(M518), CNNDThe University of Western AustraliaCrawleyAustralia
  2. 2., Centre Neuromuscular Disorders (CNND)The University of Western AustraliaCrawleyAustralia
  3. 3., CNNDThe University of Western AustraliaCrawleyAustralia

Bibliographic information