Untranslated Gene Regions and Other Non-coding Elements

Regulation of Eukaryotic Gene Expression

  • Lucy W. Barrett
  • Sue Fletcher
  • Steve D. Wilton

Part of the SpringerBriefs in Biochemistry and Molecular Biology book series (BRIEFSBIOCHEM)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Lucy W. Barrett, Sue Fletcher, Steve D. Wilton
    Pages 1-56

About this book


There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.​


DNA regulation Gene expression Introns Junk DNA Non-coding RNA Promotors

Authors and affiliations

  • Lucy W. Barrett
    • 1
  • Sue Fletcher
    • 2
  • Steve D. Wilton
    • 3
  1. 1.(M518), CNNDThe University of Western AustraliaCrawleyAustralia
  2. 2., Centre Neuromuscular Disorders (CNND)The University of Western AustraliaCrawleyAustralia
  3. 3., CNNDThe University of Western AustraliaCrawleyAustralia

Bibliographic information

  • DOI
  • Copyright Information The Author(s) 2013
  • Publisher Name Springer, Basel
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-0348-0678-7
  • Online ISBN 978-3-0348-0679-4
  • Series Print ISSN 2211-9353
  • Series Online ISSN 2211-9361
  • Buy this book on publisher's site