© 2012

Twenty Years of G-CSF

Clinical and Nonclinical Discoveries

  • Graham Molineux
  • MaryAnn Foote
  • Tara Arvedson

Part of the Milestones in Drug Therapy book series (MDT)

Table of contents

  1. Front Matter
    Pages i-xxii
  2. Basic Science

    1. Front Matter
      Pages 1-1
    2. George Morstyn
      Pages 3-13
    3. Tara L. Arvedson, Mike J. Giffin
      Pages 61-82
    4. Hoainam T. Nguyen-Jackson, Huiyuan Zhang, Stephanie S. Watowich
      Pages 83-105
  3. Use of rHuG-CSF in the Oncology Setting

    1. Front Matter
      Pages 107-107
    2. Tara L. Arvedson, Graham Molineux
      Pages 151-168
    3. Mojtaba Akhtari, Lori Maness
      Pages 183-193
    4. Pia Raanani, Ronit Gurion, Anat Gafter-Gvili, Isaac Ben-Bassat, Ofer Shpilberg
      Pages 195-210
    5. William Renwick
      Pages 225-247
    6. Ashanka Beligaswatte, Ian Lewis, Luen Bik To
      Pages 249-275
  4. Use of rHuG-CSF in Non-Oncology Setting

    1. Front Matter
      Pages 277-277
    2. David C. Dale, Audrey Anna Bolyard
      Pages 279-291

About this book


Granulocyte colony-stimulating factor (G-CSF or GCSF) is a secreted glycoprotein that stimulates the proliferation and differentiation of granulocyte precursor cells, and induces mobilization of peripheral blood progenitor cells from the bone marrow. Development of recombinant human G-CSF has had a profound impact on the treatment of many diseases, including severe chronic neutropenia and cancer, and has enabled peripheral stem cell transplantation to supplant bone marrow transplantation in the autologous setting.

This Milestones in Drug Therapy volume describes the experience of the last 20 years of treatment with recombinant human G-CSF, including the basic science, the use of recombinant human G-CSF in both the oncology and nononcology settings, and the safety and economics of its use. Many of the authors were the original investigators of recombinant human G-CSF and other authors are key researchers who provide their outlook for the next 20 years for use of and research with recombinant human G-CSF.


hematopoiesis infectious diseases neutropenia oncology pharmacology

Editors and affiliations

  • Graham Molineux
    • 1
  • MaryAnn Foote
    • 2
  • Tara Arvedson
    • 3
  1. 1.Amgen Inc.Thousand OaksUSA
  2. 2.MA Foote AssociatesWestlake VillageUSA
  3. 3.Amgen, Inc.Thousand OaksUSA

Bibliographic information