The Inflammasomes

  • Isabelle Couillin
  • Virginie Pétrilli
  • Fabio Martinon

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Virginie Pétrilli, Fabio Martinon
    Pages 1-16
  3. Tyler K. Ulland, Fayyaz S. Sutterwala
    Pages 37-50
  4. Christopher R. Lupfer, Thirumala-Devi Kanneganti
    Pages 51-64
  5. Olaf Gross, Christina J. Thomas, Laura E. Layland
    Pages 65-83
  6. Pablo Pelegrín
    Pages 101-121
  7. Frank L. van de Veerdonk, Mihai G. Netea
    Pages 123-132
  8. Olivier Gaide
    Pages 133-149
  9. Lionel Apetoh
    Pages 151-163
  10. Bernhard Ryffel, Dieudonnée Togbe, Isabelle Couillin
    Pages 165-182
  11. Marco Gattorno, Anna Rubartelli
    Pages 183-195
  12. Juan-Carlos Hernandez, Cherilyn M. Sirois, Eicke Latz
    Pages 197-208
  13. Helen J. Lachmann
    Pages 209-220
  14. Back Matter
    Pages 221-223

About this book


The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene, encoding the human NLRP3 protein, responsible for several autoinflammatory disorders such as the Muckle Wells syndrome. Since, the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described. These inflammasomes sense a wide variety of pathogens and danger signals and are key players in the inflammatory response. With the contributions of leading international experts in the field, this book provides an extensive overview of the current knowledge of inflammasome biology and their role in health and disease.


Activation Cytokines Immunology Inflammasome Inflammation Pathology

Editors and affiliations

  • Isabelle Couillin
    • 1
  • Virginie Pétrilli
    • 2
  • Fabio Martinon
    • 3
  1. 1.Institut de Transgénose, Labo. d'Immunologie etCNRSOrléans CX 2France
  2. 2.CNRS UMR 5201, Labo. Génétique et CancerUniversité de Lyon ILyonFrance
  3. 3.Dept. Immunology & Infectious, DiseasesHarvard School of Public HealthBostonUSA

Bibliographic information