Treatment and Prevention of Malaria

Antimalarial Drug Chemistry, Action and Use

  • Henry M. Staines
  • Sanjeev Krishna

Part of the Milestones in Drug Therapy book series (MDT)

Table of contents

  1. Front Matter
    Pages i-x
  2. Paul M. O’Neill, Victoria E. Barton, Stephen A. Ward, James Chadwick
    Pages 19-44
  3. David J. Sullivan
    Pages 45-68
  4. Norman C. Waters, Michael D. Edstein
    Pages 69-94
  5. Francois Nosten, Penelope A. Phillips-Howard, Feiko O. ter Kuile
    Pages 95-111
  6. Dejan M. Opsenica, Bogdan A. Šolaja
    Pages 191-211
  7. Andrea Ecker, Adele M. Lehane, David A. Fidock
    Pages 249-280
  8. Patricia Schlagenhauf, Eskild Petersen
    Pages 281-292
  9. David Bell, Mark D. Perkins
    Pages 293-307
  10. Back Matter
    Pages 309-315

About this book

Introduction

Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions.  

Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail.

Keywords

Antimalarial drugs Artemisinin Chemoprophylaxis Combination therapy Disease control Drug resistance Malaria Plasmodium

Editors and affiliations

  • Henry M. Staines
    • 1
  • Sanjeev Krishna
    • 2
  1. 1.Centre for Infection, Div. Cellular & Molecular MedicineSt. George's University of LondonLondonUnited Kingdom
  2. 2.Medical School, Dept. Infectious DiseasesSt. George´s HospitalLondonUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-0346-0480-2
  • Copyright Information Springer Basel AG 2012
  • Publisher Name Springer, Basel
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-0346-0479-6
  • Online ISBN 978-3-0346-0480-2
  • About this book