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Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense

  • Chang-Hwei Chen
Book
  • 1.4k Downloads

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Chang-Hwei Chen
    Pages 1-9
  3. Chang-Hwei Chen
    Pages 35-44
  4. Chang-Hwei Chen
    Pages 45-58
  5. Chang-Hwei Chen
    Pages 205-219
  6. Chang-Hwei Chen
    Pages 221-234
  7. Back Matter
    Pages 235-239

About this book

Introduction

This book provides a comprehensive, organized, and concise overview of Xenobiotic Metabolic Enzymes and their health implications. The subjects addressed are broad in scope with an emphasis on recent advances in research on biochemical and biomedical aspects of these enzymes. The xenobiotics discussed include not just drugs, but also food, smoke, and other environmental chemicals. 


The subjects covered in this work include: metabolic enzymes and their catalyzed reactions, reactive intermediates generated from metabolic activation, oxidative stress mediated by electrophilic reactive intermediates, bioactivation - mediated cellular and functional damages, activation of Nrf2 – ARE pathway, genetic variations affecting metabolic enzyme expression, enzyme polymorphisms affecting xenobiotic - mediated toxicity, induction of metabolic enzymes for health benefits, and a diversity of metabolic enzyme modulators.

Keywords

xenobiotics metabolic enzymes bioactivation oxidative stress antioxidant defense enzyme indivicibility

Authors and affiliations

  • Chang-Hwei Chen
    • 1
  1. 1.Institute for Health and the Environment and Department of Biomedical SciencesUniversity at Albany, State University of New York, 5 University PlaceRensselaerUSA

Bibliographic information