New Therapies to Prevent or Cure Auditory Disorders

  • Sylvie Pucheu
  • Kelly E. Radziwon
  • Richard Salvi

Table of contents

  1. Front Matter
    Pages i-vii
  2. Shinichi Someya, Christina Rothenberger, Mi-Jung Kim
    Pages 1-21
  3. Celia Escabi, Monica Trevino, Eric Bielefeld, Edward Lobarinas
    Pages 23-50
  4. Chaitanya Mamillapalli, Asmita Dhukhwa, Sandeep Sheth, Debashree Mukherjea, Leonard P. Rybak, Vickram Ramkumar
    Pages 51-87
  5. Kelly E. Radziwon, Senthilvelan Manohar, Benjamin Auerbach, Xiaopeng Liu, Guang-Di Chen, Richard Salvi
    Pages 135-157
  6. A. Laboulais, S. Malmström, C. Dejean, M. Cardoso, T. Le Meur, L. Almeida et al.
    Pages 159-186

About this book


This volume focuses on new molecular therapies that aim to prevent specific pathologies of the ear, like age-related hearing loss, noise-induced hearing loss and ototoxicity. The book discusses the regenerative capacity of hair cells in the inner ear, exploring the idea that hair cells’ capacity to regenerate appears “repressed” in adult mammals, but that it will be possible to re-activate regeneration with an appropriate therapeutic approach. The book provides an overview of inflammatory and immune cells in the cochlear lateral wall, the pathways involved in cochlear damage, and their potential as therapeutic targets. It also describes the significant advances in animal models which play an important role in revealing the underlying mechanisms and treatment for tinnitus and hyperacusis. Finally, the book describes two new automatic and robust measures to evaluate hearing loss and tinnitus in preclinical models.


hearing loss drug therapy noise-induced ototoxicity tinnitus hyperacusis

Editors and affiliations

  • Sylvie Pucheu
    • 1
  • Kelly E. Radziwon
    • 2
  • Richard Salvi
    • 3
  1. 1.CILcareAdvanced Solution for Drug Development in Hearing DisorderMontpellierFrance
  2. 2.Center for Hearing and DeafnessUniversity at BuffaloBuffaloUSA
  3. 3.Center for Hearing and DeafnessUniversity at BuffaloBuffaloUSA

Bibliographic information