© 2020

Notch Signaling in Embryology and Cancer

Molecular Biology of Notch Signaling

  • Jörg Reichrath
  • Sandra Reichrath

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1227)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Brendan McIntyre, Takayuki Asahara, Cantas Alev
    Pages 9-27
  3. Bhawana Maurya, Satya Surabhi, Ashim Mukherjee, Mousumi Mutsuddi
    Pages 69-79
  4. Laura Marquez-Exposito, Elena Cantero-Navarro, Raúl R. Rodrigues-Diez, Macarena Orejudo, Antonio Tejera-Muñoz, Lucia Tejedor et al.
    Pages 81-94
  5. Amanda Salviano-Silva, Fernanda Costa Brandão Berti, Sara Cristina Lobo-Alves, Patricia Savio de Araujo-Souza, Angelica Beate Winter Boldt, Danielle Malheiros
    Pages 107-129
  6. G. Tsaouli, A. Barbarulo, A. Vacca, I. Screpanti, M. P. Felli
    Pages 145-164
  7. Back Matter
    Pages 165-172

About this book


This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It summarizes the newest achievements on this topic from Notch’s flag-ship function in the development of the embryo and for various inherited diseases to the Notch signaling pathway’s role in the development of leukemia and in a number of cancers, including skin cancer, intestinal cancer and others. Additionally, the emerging new role of the Notch signaling pathway as a promising target for prevention and therapy of various diseases, including cancer, is discussed. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role for embryologic tissue patterning, for stem cells, in senescence, and on the regulation of Notch signaling by epigenetic and other factors including microRNAs, long non-codingRNAs, and more. 

Taken as a whole, with its companion books – Notch Signaling in Embryology and Notch Signaling in Cancer – this is a definitive discussion of the topic, presented by internationally-recognized contributors.  Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.


Notch Notch Signaling Embryology Microbiome and Cancer Notch and senescence Regulation of Notch Signaling Cancer Stem Cells Stem Cell Niche

Editors and affiliations

  • Jörg Reichrath
    • 1
  • Sandra Reichrath
    • 2
  1. 1.Department of DermatologyThe Saarland University HospitalHomburgGermany
  2. 2.Department of DermatologyThe Saarland University HospitalHomburgGermany

About the editors

Sandra and Jörg Reichrath are working at the Clinic for Dermatology; Allergology and Venerology of the Saarland University Hospital in Homburg/Saar. Germany. Main research interests include photobiology, carcinogenesis of skin cancer (with a special interest for the role of ultraviolet radiation, Notch and p53), and the relevance of the vitamin D endocrine system for health and disease. Sandra received her academic degrees (Dipl. Biol. and Dr. rer. nat.) from the Albert-Ludwigs-Universität (Freiburg, Germany) and from Saarland University (Saarbrücken/Homburg, Germany), respectively. Jörg received his academic degrees (Dr. med., venia legendi) from Saarland University (Saarbrücken/Homburg, Germany). He has been awarded numerous prizes including the Arnold-Rikli-Prize in 2006.

Bibliographic information

  • Book Title Notch Signaling in Embryology and Cancer
  • Book Subtitle Molecular Biology of Notch Signaling
  • Editors Jörg Reichrath
    Sandra Reichrath
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer Nature Switzerland AG 2020
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-030-36421-2
  • Softcover ISBN 978-3-030-36424-3
  • eBook ISBN 978-3-030-36422-9
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 2
  • Number of Pages XIII, 172
  • Number of Illustrations 1 b/w illustrations, 31 illustrations in colour
  • Topics Cancer Research
    Cell Biology
  • Buy this book on publisher's site