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Notch Signaling in Embryology and Cancer

Molecular Biology of Notch Signaling

  • Jörg Reichrath
  • Sandra Reichrath
Book

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1227)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Brendan McIntyre, Takayuki Asahara, Cantas Alev
    Pages 9-27
  3. Bhawana Maurya, Satya Surabhi, Ashim Mukherjee, Mousumi Mutsuddi
    Pages 69-79
  4. Laura Marquez-Exposito, Elena Cantero-Navarro, Raúl R. Rodrigues-Diez, Macarena Orejudo, Antonio Tejera-Muñoz, Lucia Tejedor et al.
    Pages 81-94
  5. Amanda Salviano-Silva, Fernanda Costa Brandão Berti, Sara Cristina Lobo-Alves, Patricia Savio de Araujo-Souza, Angelica Beate Winter Boldt, Danielle Malheiros
    Pages 107-129
  6. G. Tsaouli, A. Barbarulo, A. Vacca, I. Screpanti, M. P. Felli
    Pages 145-164
  7. Back Matter
    Pages 165-172

About this book

Introduction

This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It summarizes the newest achievements on this topic from Notch’s flag-ship function in the development of the embryo and for various inherited diseases to the Notch signaling pathway’s role in the development of leukemia and in a number of cancers, including skin cancer, intestinal cancer and others. Additionally, the emerging new role of the Notch signaling pathway as a promising target for prevention and therapy of various diseases, including cancer, is discussed. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role for embryologic tissue patterning, for stem cells, in senescence, and on the regulation of Notch signaling by epigenetic and other factors including microRNAs, long non-codingRNAs, and more. 

Taken as a whole, with its companion books – Notch Signaling in Embryology and Notch Signaling in Cancer – this is a definitive discussion of the topic, presented by internationally-recognized contributors.  Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.

Keywords

Notch Notch Signaling Embryology Microbiome and Cancer Notch and senescence Regulation of Notch Signaling Cancer Stem Cells Stem Cell Niche

Editors and affiliations

  • Jörg Reichrath
    • 1
  • Sandra Reichrath
    • 2
  1. 1.Department of DermatologyThe Saarland University HospitalHomburgGermany
  2. 2.Department of DermatologyThe Saarland University HospitalHomburgGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-030-36422-9
  • Copyright Information Springer Nature Switzerland AG 2020
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-030-36421-2
  • Online ISBN 978-3-030-36422-9
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site