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© 2020

Mucosal Delivery of Drugs and Biologics in Nanoparticles

  • Pavan Muttil
  • Nitesh K. Kunda
Book

Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 41)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Background

    1. Front Matter
      Pages 1-1
    2. Tejashri Chavan, Pavan Muttil, Nitesh K. Kunda
      Pages 3-26
    3. Kalpesh Vaghasiya, Ankur Sharma, Eupa Ray, Suneera Adlakha, Rahul Kumar Verma
      Pages 27-57
  3. Nanoparticle-Based Mucosal Delivery of Drugs and Biologics

    1. Front Matter
      Pages 59-59
    2. Kan Kaneko, Nashwa Osman, Valeria Carini, Giulia Scagnetti, Imran Saleem
      Pages 61-82
    3. Vineela Parvathaneni, Nishant S. Kulkarni, Vivek Gupta
      Pages 83-106
    4. Andrea C. Ortiz, Javier O. Morales
      Pages 107-124
    5. Joanne M. Ramsey, Alice McCloskey, Rachel Gaul, Elena Fernandez Fernandez, Louise Sweeney, Catherine M. Greene et al.
      Pages 125-154
    6. Rikhav P. Gala, Lotika Bajaj, Amit Bansal, Keegan Braz Gomes, Devyani Joshi, Ipshita Menon et al.
      Pages 155-175
    7. Achraf Noureddine, Jonas G. Croissant, Harrison O. Davis, Lorenza I. Friedrich, Rita E. Serda
      Pages 177-204
  4. Host Interactions with Nanoparticles

  5. Back Matter
    Pages 269-277

About this book

Introduction

This book focuses on the application of nanotechnology to deliver drugs and biological agents by the mucosal routes of administration i.e. nasal, pulmonary, buccal, and oral routes.It provides an overview of nanotechnology in drug delivery with a description of different types of nanoparticles, methods of preparation and characterization, and functionalization for site-specific drug delivery. Mucosal Delivery of Drugs and Biologics in Nanoparticles emphasize the use of nanoparticles in treating various cancers and infectious diseases. It broadens the use of nanoparticles by including biologics, including vaccines and immunotherapies, apart from drugs. It acknowledges the concerns around the potential toxicity of nanoparticles to the host; few chapters will discuss the biodistribution of these nanoparticles when mucosal routes of administration are employed. Further, the interaction of nanoparticles with the host’s immune cells is discussed. Moreover,it reviews the regulatory aspects of nanotechnology in product development, especially when delivered by the mucosal route of administration. Lastly, discusses the challenges and opportunities to manufacture nanoparticles on an industrial scale. This book will be the first of its kind to focus on the design, development and delivery of nanoparticles when administered by different mucosal routes.

Keywords

nanomedicine drugs and biologics nanoparticulate vaccines nano particle pharmacokinetics and pharmacodynamics theranostics nanoparticel manufacturing

Editors and affiliations

  • Pavan Muttil
    • 1
  • Nitesh K. Kunda
    • 2
  1. 1.Department of Pharmaceutical SciencesCollege Pharmacy, University of New MexicoAlbuquerqueUSA
  2. 2.Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt. John’s UniversityJamaicaUSA

About the editors

Dr. Muttil is an Associate Professor with tenure in the Department of Pharmaceutical Sciences, College of Pharmacy, at the University of New Mexico (UNM), NM, USA. Dr. Muttil’s expertise is in developing novel delivery systems (micro-and nanotechnology) for vaccines and drugs against infectious diseases and cancers. His laboratory focuses on the formulation and testing of vaccines and drugs in animal models, as a needle-free delivery strategy. Some of the projects being pursued in his laboratory include pulmonary drug delivery for lung cancer, pulmonary immunization against tuberculosis, needle-free vaccination strategies against bioterrorism agents and formulating immunotherapeutic agents against cancers and infectious diseases. Dr. Muttil was educated in India, receiving his bachelor’s in pharmacy in 1999 from the Dr. K.N. Modi Institute of Pharmaceutical and Educational Research in 1999, his master’s in pharmacy from the Birla Institute of Technology & Science, Pilani, in 2001 and his PhD in pharmaceutics from the Central Drug Research Institute, Lucknow, in 2006. He did post-doctoral research in aerosol drug and vaccine delivery at the University of North Carolina, Chapel Hill, before coming to UNM in 2010. Dr. Muttil was awarded the Bill and Melinda Gates Grand Challenges Exploration grant in 2012, an award that is bestowed to only a few innovative ideas from around the world. Currently, he is also the chair of the UNM College of Pharmacy admissions committee.

Dr. Kunda is an Assistant Professor in the Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences at the St. John’s University, New York, USA. Prior to joining St. John’s, Dr. Kunda was a post-doctoral fellow at the College of Pharmacy, University of New Mexico, Albuquerque, NM, with a research focus in aerosol drug and vaccine delivery. Dr. Kunda received his Bachelor’s in Pharmacy (Honors) from Birla Institute of Technology & Science-Pilani (BITS-Pilani), India, Master’s in Drug Delivery from the London School of Pharmacy, London, UK and a Ph.D. in Formulation and Drug Delivery from Liverpool John Moores University in Liverpool, UK. Dr. Kunda’s dissertation focused on developing a novel pneumococcal vaccine that can be inhaled as a dry powder.
Dr. Kunda’s research is multi-disciplinary and his current research interests include the use of nanotechnology in developing therapeutics against infectious disease and cancer, synthesizing polymeric nanoparticles and attaching targeting moieties for site-specific delivery, formulation of amorphous solid dispersions, immunotherapy, and drug and vaccine formulation for pulmonary delivery. Dr. Kunda’s laboratory specializes in developing dry powder biologics that do not require cold-chain for storage and transport thereby decreasing the cost of biologics-based products significantly. Dr. Kunda serves as an editorial board member of PLoS One and as a Review Editor for the Vaccines and Molecular Therapeutics section of the Frontiers in Immunology and Frontiers in Public Health journals. In addition, Dr. Kunda acts a reviewer for many high-impact journals such as International Journal of Pharmaceutics, ACS Applied Materials & Interfaces, Toxicology in vitro, Pharmaceutics, Microorganisms, Pharmaceuticals, Human Vaccines & Immunotherapeutics, and PLoS One.

Bibliographic information

  • Book Title Mucosal Delivery of Drugs and Biologics in Nanoparticles
  • Editors Pavan Muttil
    Nitesh K. Kunda
  • Series Title AAPS Advances in the Pharmaceutical Sciences Series
  • Series Abbreviated Title AAPS Adv. Pharmaceutical Sciences
  • DOI https://doi.org/10.1007/978-3-030-35910-2
  • Copyright Information American Association of Pharmaceutical Scientists 2020
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-030-35909-6
  • Softcover ISBN 978-3-030-35912-6
  • eBook ISBN 978-3-030-35910-2
  • Series ISSN 2210-7371
  • Series E-ISSN 2210-738X
  • Edition Number 1
  • Number of Pages VIII, 277
  • Number of Illustrations 10 b/w illustrations, 42 illustrations in colour
  • Topics Pharmaceutical Sciences/Technology
  • Buy this book on publisher's site