© 2020

Tumor Microenvironment

Signaling Pathways – Part A

  • Alexander Birbrair

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1223)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Wuling Liu, Krishnapriya M. Varier, Klarke M. Sample, Eldad Zacksenhaus, Babu Gajendran, Yaacov Ben-David
    Pages 17-30
  3. Stephan Niland, Johannes A. Eble
    Pages 31-67
  4. Chiara Bazzichetto, Fabiana Conciatori, Italia Falcone, Ludovica Ciuffreda
    Pages 69-80
  5. Kelly D. McCall, Maria Muccioli, Fabian Benencia
    Pages 81-97
  6. Gabriela Schneider
    Pages 129-153
  7. Jin-Qing Liu, Aiyan Hu, Jianmin Zhu, Jianyu Yu, Fatemeh Talebian, Xue-Feng Bai
    Pages 155-165
  8. Back Matter
    Pages 167-170

About this book


Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. Multiple signaling pathways are covered, including S1P, neuregulin, Notch, erythropoietin, Rho-ROCK, mTOR, and more.

Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Signaling Pathways – Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.


Estrogen signaling tumor microenvironment estrogen tumor RANK signaling tumor microenvironment Neuropilins signaling tumor microenvironment Eph/ephrin signaling tumor Rho-ROCK signaling tumor mTOR Signaling Tumor Microenvironment Renin-angiotensin system tumor Nitric oxide signaling tumor Interferon signaling tumor microenvironment Frizzled4 signaling tumor microenvironment nitric oxide signaling tumor toll receptor signaling tumor

Editors and affiliations

  • Alexander Birbrair
    • 1
  1. 1.Columbia University Medical Center, Department of Radiology, New York, NY, USAFederal University of Minas Gerais, Department of PathologyBelo HorizonteBrazil

About the editors

Alexander Birbrair received his Bachelor’s Biomedical degree from Santa Cruz State University in Brazil. He moved to North Carolina, where he finished his PhD in Neuroscience under the mentorship of Osvaldo Delbono. Then, he joined as a posdoc in Stem Cell Biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA).

Bibliographic information

  • Book Title Tumor Microenvironment
  • Book Subtitle Signaling Pathways – Part A
  • Editors Alexander Birbrair
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer Nature Switzerland AG 2020
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-030-35581-4
  • Softcover ISBN 978-3-030-35584-5
  • eBook ISBN 978-3-030-35582-1
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XI, 170
  • Number of Illustrations 3 b/w illustrations, 35 illustrations in colour
  • Topics Cell Biology
    Cancer Research
  • Buy this book on publisher's site


“It is intended for students and researchers of cancer biology. … This book is of very good quality and has great potential utility for researchers investigating cancer biology and various aspects of the tumor microenvironment.” (George M Rodgers, Doody's Book Reviews, May 29, 2020)