Clinical Trials

  • Timothy M. Pawlik
  • Julie A. Sosa

Part of the Success in Academic Surgery book series (SIAS)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Janice Hu, Justin Barr, Georgia M. Beasley
    Pages 1-15
  3. Kara K. Rossfeld, Jordan M. Cloyd, Elizabeth Palmer, Timothy M. Pawlik
    Pages 17-31
  4. Puneet Singh, Yu Shen, Kelly K. Hunt
    Pages 37-45
  5. Emily Z. Keung, Lisa M. McElroy, Daniela P. Ladner, Elizabeth G. Grubbs
    Pages 47-58
  6. Peter G. Stock, Rita Mukhtar, Hila Ghersin, Allison Stover Fiscalini, Laura Esserman
    Pages 59-76
  7. Mihir M. Shah, Darren R. Carpizo
    Pages 77-85
  8. M. Abdullah Arain, Adil H. Haider, Zain G. Hashmi
    Pages 101-115
  9. Douglas S. Swords, Benjamin S. Brooke
    Pages 117-135
  10. Rachael A. Callcut
    Pages 137-142
  11. Benjamin K. Poulose
    Pages 143-149
  12. Shuab Omer, Faisal G. Bakaeen
    Pages 151-166
  13. H. Richard Alexander Jr., Howard S. Hochster
    Pages 167-179
  14. Warren Gasper, Michael Conte
    Pages 181-186
  15. Peter C. Minneci, Katherine J. Deans
    Pages 187-194
  16. Casey J. Allen, Giampaolo Perri, Matthew H. G. Katz
    Pages 195-212
  17. Marc A. Gladman
    Pages 213-228
  18. Lindsey M. Zhang, Cord Sturgeon, Anthony D. Yang, Ryan P. Merkow
    Pages 229-236
  19. Back Matter
    Pages 251-258

About this book


This extensively revised second edition is a unique and portable handbook focusing on clinical trials in surgery. It includes new educational materials addressing the rapid evolution of novel research methodologies in basic science, clinical and educational research. The underlying principles of clinical trials, trial design, the development of a study cohort, statistics, data safety, data monitoring, and trial publication for device and drug trials are also discussed. 

Clinical Trials provides a comprehensive resource on clinical trials in surgery and describes all the stages of a clinical trial from generating a hypothesis through to trial publication and is a valuable resource for all practicing and trainee academic surgeons.


Clinical trials Education Surgery Regulatory Issues Cooperative trials International trials Pragmatic clinical trials

Editors and affiliations

  • Timothy M. Pawlik
    • 1
  • Julie A. Sosa
    • 2
  1. 1.Chair, Department of Surgery The Urban Meyer III and Shelley Meyer Chair for Cancer ResearchThe Ohio State University Wexner MedicalColumbusUSA
  2. 2.Leon Goldman, MD Distinguished Professor of Surgery and Chair Department of SurgeryUniversity of California, San FranciscoSan FranciscoUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Switzerland AG 2020
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-030-35487-9
  • Online ISBN 978-3-030-35488-6
  • Series Print ISSN 2194-7481
  • Series Online ISSN 2194-749X
  • Buy this book on publisher's site