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Nanovaccines

An Innovative Technology to Fight Human and Animal Diseases

  • Sergio Rosales-Mendoza
  • Omar González-Ortega
Book

Table of contents

  1. Front Matter
    Pages i-x
  2. Sergio Rosales-Mendoza, Omar González-Ortega
    Pages 1-14
  3. Sergio Rosales-Mendoza, Omar González-Ortega
    Pages 15-35
  4. Sergio Rosales-Mendoza, Omar González-Ortega
    Pages 37-60
  5. Sergio Rosales-Mendoza, Omar González-Ortega
    Pages 61-103
  6. Sergio Rosales-Mendoza, Omar González-Ortega
    Pages 105-130
  7. Sergio Rosales-Mendoza, Omar González-Ortega
    Pages 131-157
  8. Sergio Rosales-Mendoza, Omar González-Ortega
    Pages 159-179
  9. Sergio Rosales-Mendoza, Omar González-Ortega
    Pages 181-231
  10. Sergio Rosales-Mendoza, Omar González-Ortega
    Pages 233-265
  11. Sergio Rosales-Mendoza, Omar González-Ortega
    Pages 267-318
  12. Sergio Rosales-Mendoza, Omar González-Ortega
    Pages 319-336
  13. Back Matter
    Pages 337-343

About this book

Introduction

This book provides a compilation of the current developments in mucosal nanovaccines, which are an attractive approach to fight against infectious and non-communicable diseases. Since nanomaterials possess unique properties; many of them have a positive effect on vaccine efficacy when used as antigen carriers and have been applied in vaccinology with significant advances over the past years. This book addresses the methodologies for mucosal nanovaccines synthesis; based on the following nanomaterials: gold, PLGA, silica, and chitosan nanoparticles; as well as nanogels, carbon nanotubes, liposomes, and Virus-like particles. A description of the immunogenic properties of the mucosal nanovaccines is presented, highlighting the improvements achieved with this approach when compared to conventional formulations. Mucosal vaccines constitute the most practical immunization approach since they are easy to administer (promoting patient´s comfort and increasing compliance), allow triggering relevant immune responses at both the site of administration and distant compartments, and thus may protect the main entry portal for pathogens (oral, nasal, and genital mucosae). In this context, the potential of nanovaccines to result in new mucosal formulations in the benefit of global health is analyzed.     

  • Covers the synthesis and functionalization of nanomaterials for the development of nanovaccines;
  • Discusses the underlying mechanisms involved in the induction of immune responses through mucosal compartments and the advantages of nanomaterials in the formulation of nanovaccines;
  • Transmits the state of the art for the development of mucosal nanovaccines;
  • Provides routes for the design and evaluation of mucosal nanovaccines;
  • Presents key perspectives for the field of mucosal vaccine development.


Keywords

Vaccinology Gastrointestinal immune system Pulmonary immune system Nasal immune system Mucosal nanovaccines Gold-based mucosal nanovaccines PLGA-based mucosal nanovaccines Silica-based mucosal nanovaccines Chitosan-based mucosal nanovaccines Lipid-based mucosal nanovaccines

Authors and affiliations

  • Sergio Rosales-Mendoza
    • 1
  • Omar González-Ortega
    • 2
  1. 1.Facultad de Ciencias Químicas, Centro de Investigación en Ciencias de la Salud y BiomedicinaUniversidad Autónoma de San Luis PotosíSan Luis PotosíMexico
  2. 2.Facultad de Ciencias QuímicasUniversidad Autónoma de San Luis PotosíSan Luis PotosíMexico

Bibliographic information