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Molecular Genetics of Inflammatory Bowel Disease

  • Charlotte Hedin
  • John D. Rioux
  • Mauro D'Amato

Table of contents

  1. Front Matter
    Pages i-x
  2. The Foundation of IBD Genetics: Human and Animal Models

    1. Front Matter
      Pages 1-1
    2. Oscar E. Diaz, Rodrigo A. Morales, Srustidhar Das, Eduardo J. Villablanca
      Pages 47-76
  3. The Genetic and Molecular Makeup of IBD

    1. Front Matter
      Pages 77-77
    2. Jeffrey C. Barrett, Mark J. Daly
      Pages 79-89
    3. Fatemeh Hadizadeh, Charlie W. Lees, Catherine Labbé, John D. Rioux, Miles Parkes, Alexandra Zhernakova et al.
      Pages 91-115
    4. Urko M. Marigorta
      Pages 141-156
    5. Ho-Su Lee, Isabelle Cleynen
      Pages 157-182
    6. Antonella Fazio, Dora Bordoni, Philip Rosenstiel
      Pages 183-201
    7. Matthias Hübenthal, Andre Franke, Simone Lipinski, Simonas Juzėnas
      Pages 203-230
    8. Shixian Hu, Alexander Kurilshikov, Alexandra Zhernakova, Rinse Weersma
      Pages 231-248
  4. Pathogenetic Pathways in IBD

    1. Front Matter
      Pages 249-249
    2. Maria Kaparakis-Liaskos, Ashleigh Goethel, Dana J. Philpott
      Pages 251-280
    3. Kevin J. Maloy
      Pages 281-303
    4. Natalia Nedelsky, Petric Kuballa, Adam B. Castoreno, Ramnik J. Xavier
      Pages 305-328
    5. Celia Escudero-Hernández, Stefan Koch
      Pages 329-345
    6. Aonghus Lavelle, Harry Sokol
      Pages 347-377
  5. Concluding Remarks and Future Perspective

    1. Front Matter
      Pages 379-379
    2. Ryan C. Ungaro, Jean-Frederic Colombel
      Pages 381-389
  6. Back Matter
    Pages 391-402

About this book

Introduction

Inflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowledge, with particular focus on the molecular and genetic mechanisms at the basis of IBD.

Invited experts, at the frontline of IBD research, introduce basic concepts in the pathophysiology of IBD and its two major forms Crohn’s disease and ulcerative colitis, provide a historical perspective and highlight latest discoveries of IBD genetic research, describe how this information has helped to unravel novel pathogenetic pathways, and formulate a vision for future investigations and their clinical application in IBD.

State-of-the-art information contained in this book is an exceptional resource for all those in the biomedical field with a specific interest in IBD, including basic scientists, gastroenterologists, GI specialist doctors and research nurses, but also medical and biomedical students.

Keywords

IBD genetics genomics translational research metagenomics gut microbiota

Editors and affiliations

  • Charlotte Hedin
    • 1
  • John D. Rioux
    • 2
  • Mauro D'Amato
    • 3
  1. 1.Gastroenterology unit, Patient Area GastroenterologyDermatovenereology and Rheumatology, Karolinska University HospitalStockholmSweden
  2. 2.Montreal Heart Institute and Université de MontréalMontréalCanada
  3. 3.School of Biological SciencesMonash UniversityClaytonAustralia

Bibliographic information