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Endometrial Gene Expression

An Emerging Paradigm for Reproductive Disorders

  • Joanne Kwak-Kim
Book

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Takeshi Kurita, Jumpei Terakawa
    Pages 1-32
  3. Li Wu, Aihua Liao, Alice Gilman-Sachs, Joanne Kwak-Kim
    Pages 51-66
  4. Svetlana Dambaeva, Kenneth D. Beaman
    Pages 67-74
  5. Maria Ruiz-Alonso, Jose Miravet-Valenciano, Pilar López, Carlos Simón
    Pages 91-102
  6. Jin Huang, Ruizhe Zhang, Chi Chiu Wang, Tin Chiu Li
    Pages 103-116
  7. Carolyn Coulam
    Pages 117-124
  8. Jessica E. Miller, Lindsey K. Symons, Ryan M. Marks, Chandrakant Tayade
    Pages 141-158
  9. Niraj Joshi, Ren-Wei Su, Asgerally Fazleabas
    Pages 159-180
  10. Swati Agrawal, Christian M. Becker
    Pages 181-197
  11. Lianghui Diao, Songchen Cai, Jinli Ding, Yong Zeng
    Pages 199-214
  12. Back Matter
    Pages 215-220

About this book

Introduction

The endometrium goes through cyclical changes under the influence of hormones, and immune effectors in the endometrium change their populations cyclically as well. Dynamic changes in immune effectors determine endometrial cytokine and chemokine milieus and, consequently, the endometrial immune response. Endometrial immune responses have been shown to be important for trophoblast invasion and early pregnancy. Indeed, dysregulated endometrial inflammatory immune responses are associated with reproductive failures, such as recurrent pregnancy losses, repeated implantation failure, and gynecological diseases with oncogenic potential. Hence, the investigation of endometrial gene expression may predict infertility, gynecological and oncological conditions. 

This book presents the state of the art in endometrial gene expression as well as recent developmental findings relating to reproduction and reproductive disorders. It begins with a review of the genetic regulation of urogenital tract formation and molecular mechanism underlying the physiology of menstrual cycle before moving on to the current and emerging technological advances in molecular biology. Endometrial gene expressions of immune inflammatory conditions, viral infection, metabolic and nutritional conditions, and reproductive disorders are then presented in following chapters. Examples of the use and interpretation of gene expression in clinical scenarios including recurrent pregnancy losses,  infertility and multiple implantation failures are presented with currently available endometrial gene analysis.

Utilizing the latest evidence and clinical guidelines, Endometrial Gene Expression will be a cutting-edge resource for gynecologist, reproductive immunologist, reproductive endocrinologists, obstetrician, maternal fetal medicine specialist and other health care providers in the field of reproductive medicine.  

Keywords

Cytokine IL-15 Endometrial biopsy Endometrial gene expression Endometriosis Endometrium Female infertility Gynecological malignancy HHV6 Immune profiling MicroRNA Progesterone Recurrent implantation failure Recurrent pregnancy loss Uterine fibroid

Editors and affiliations

  • Joanne Kwak-Kim
    • 1
  1. 1.Reproductive Medicine and Immunology Clinical Sciences, Obstetrics and Gynecology, Microbiology and ImmunologyChicago Medical School, Rosalind Franklin University of Medicine and ScienceVernon HillsUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-030-28584-5
  • Copyright Information Springer Nature Switzerland AG 2020
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-030-28583-8
  • Online ISBN 978-3-030-28584-5
  • Buy this book on publisher's site