© 2019

Retinal Degenerative Diseases

Mechanisms and Experimental Therapy

  • Catherine Bowes Rickman
  • Christian Grimm
  • Robert E. Anderson
  • John D. Ash
  • Matthew M. LaVail
  • Joe G. Hollyfield
Conference proceedings

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1185)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Age-Related Macular Degeneration (AMD)

    1. Front Matter
      Pages 1-1
    2. Isha Akhtar-Schaefer, Raphael Reuten, Manuel Koch, Markus Pietsch, Thomas Langmann
      Pages 3-7
    3. Anna G. Figueroa, Brian S. McKay
      Pages 15-19
    4. Mikael Klingeborn, Nikolai P. Skiba, W. Daniel Stamer, Catherine Bowes Rickman
      Pages 21-25
    5. Gloriane Schnabolk
      Pages 27-31
    6. Sean M. Silverman, Wai T. Wong
      Pages 33-37
    7. Dorota Skowronska-Krawczyk, Daniel L. Chao
      Pages 39-43
    8. Nadezda A. Stepicheva, Joseph Weiss, Peng Shang, Meysam Yazdankhah, Sayan Ghosh, Imran A. Bhutto et al.
      Pages 45-49
  3. Gene Therapies

    1. Front Matter
      Pages 63-63
    2. Shyamtanu Datta, Hui Peng, John D. Hulleman
      Pages 65-69
    3. Spencer M. Moore, Dorota Skowronska-Krawczyk, Daniel L. Chao
      Pages 85-89
    4. Nachiket D. Pendse, Veronica Lamas, Basil S. Pawlyk, Morgan L. Maeder, Zheng-Yi Chen, Eric A. Pierce et al.
      Pages 91-96
    5. Simon M. Petersen-Jones, Laurence M. Occelli, Martin Biel, Stylianos Michalakis
      Pages 103-107

About these proceedings


This book contains the proceedings of the XVIII International Symposium on Retinal Degeneration (RD2018). A majority of those who spoke  and presented posters at the meeting contributed to this volume. The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium focused on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field.

The volume presents representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.

While advances in these areas of retinal degenerations were described, there will be many new topics that either are in their infancy or did not exist at the time of the last RD Symposium, RD2016. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials.

The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those were reported at the RD2016 meeting and included in the current volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations is reflected in the volume.



animal models degneration oxidative stress carotenoids gene therapy protective therapy photoreceptor regeneration cone model cntf macular degeneration

Editors and affiliations

  • Catherine Bowes Rickman
    • 1
  • Christian Grimm
    • 2
  • Robert E. Anderson
    • 3
  • John D. Ash
    • 4
  • Matthew M. LaVail
    • 5
  • Joe G. Hollyfield
    • 6
  1. 1.Department of OphthalmologyDuke UniversityDurhamUSA
  2. 2.Department of OphthalmologyUniversity Hospital ZurichZurichSwitzerland
  3. 3.Health Sciences CenterUniversity of OklahomaOklahoma CityUSA
  4. 4.OphthalmologyUniversity of FloridaGainesvilleUSA
  5. 5.Beckman Vision CenterUniversity of California, San FranciscoSan FanciscoUSA
  6. 6.Department of OphthalmologyCase Western Reserve UniversityClevelandUSA

Bibliographic information

  • Book Title Retinal Degenerative Diseases
  • Book Subtitle Mechanisms and Experimental Therapy
  • Editors Catherine Bowes Rickman
    Christian Grimm
    Robert E. Anderson
    John D. Ash
    Matthew M. LaVail
    Joe G. Hollyfield
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-030-27377-4
  • Softcover ISBN 978-3-030-27380-4
  • eBook ISBN 978-3-030-27378-1
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XVI, 596
  • Number of Illustrations 43 b/w illustrations, 82 illustrations in colour
  • Topics Immunology
  • Buy this book on publisher's site