© 2020

OCT and Imaging in Central Nervous System Diseases

The Eye as a Window to the Brain

  • Andrzej Grzybowski
  • Piero Barboni

Table of contents

  1. Front Matter
    Pages i-x
  2. Andrzej Grzybowski, Piero Barboni
    Pages 1-5
  3. Tigran Kostanyan, Maria de los Angeles Ramos-Cadena, Gadi Wollstein, Joel S. Schuman
    Pages 7-31
  4. Aykut Aytulun, Andrés Cruz-Herranz, Lisanne Balk, Alexander U. Brandt, Philipp Albrecht
    Pages 33-39
  5. Enrico Borrelli, Srinivas R. Sadda, Akihito Uji, Giuseppe Querques
    Pages 41-54
  6. Delia Cabrera DeBuc, Gábor Márk Somfai, Gabriella Szatmáry, Edmund Arthur, Jorge A. Jimenez, Carlos Mendoza-Santiesteban et al.
    Pages 55-82
  7. Maya Koronyo-Hamaoui, Jonah Doustar, Mia Oviatt, Keith L. Black, Yosef Koronyo
    Pages 83-122
  8. Timothy E. Yap, Maja Szymanska, M. Francesca Cordeiro
    Pages 123-138
  9. Anna Bryndis Einarsdottir, Olof Birna Olafsdottir, Sveinn Hakon Hardarson
    Pages 139-145
  10. Laurel N. Vuong, Thomas R. Hedges III
    Pages 147-167
  11. Mário Luiz Ribeiro Monteiro
    Pages 169-194
  12. James V. M. Hanson, Carla A. Wicki, Praveena Manogaran, Axel Petzold, Sven Schippling
    Pages 195-233
  13. Ivan Bodis-Wollner, Shahnaz Miri, Sofya Glazman, Eric M. Shrier, Reem Deeb
    Pages 235-262
  14. Gianluca Coppola, Vincenzo Parisi, Gianluca Manni, Francesco Pierelli, Alfredo A. Sadun
    Pages 263-288
  15. Francisco J. Ascaso, Javier Mateo, Laura Cabezón, Paula Casas, Andrzej Grzybowski
    Pages 317-342
  16. Piero Barboni, Nicole Balducci, Alfredo A. Sadun
    Pages 343-364
  17. Bernardo F. Sánchez-Dalmau, Anna Camós-Carreras, Ruben Torres-Torres, Johannes Keller, Laura Sanchez-Vela, Elena H. Martínez-Lapiscina et al.
    Pages 365-374
  18. Andrzej Grzybowski, Iwona Obuchowska, Carl Arndt
    Pages 375-400
  19. Eduardo M. Normando, M. Francesca Cordeiro
    Pages 401-426

About this book


The second edition of OCT and Imaging in Central Nervous System Diseases offers updated state-of-the-art advances using optical coherence tomography (OCT) regrading neuronal loss within the retina. Detailed information on the OCT imaging and interpretation is provided for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. Covering disorders like multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, intracranial hypertension, Friedreich’s ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia, readers will given insights into effects on the retina and the and optic nerve. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment, and the use of OCT in animal models.

Similar to the first edition, this book is an excellent and richly illustrated reference for diagnosis of many retinal diseases and monitoring of surgical and medical treatment. OCT allows to study vision from of the retina to the optic tracts. Retinal axons in the retinal nerve fiber layer (RNFL) are non-myelinated until they penetrate the lamina cribrosa. Hence, the RNFL is an ideal structure for visualization of any process of neurodegeneration, neuroprotection, or regeneration. By documenting the ability of OCT to provide key information on CNS diseases, this book illustrates convincingly that the eye is indeed the “window to the brain”.


Neurodegenerative Diseases Optic Neuropathy Optical Coherence Topography Retinal Nerve Fiber Layer Neuro-Ophthalmology Imaging

Editors and affiliations

  • Andrzej Grzybowski
    • 1
  • Piero Barboni
    • 2
  1. 1.University of Warmia and MazuryOlsztynPoland
  2. 2.Studio Oculistico d’AzeglioBolognaItaly

About the editors

Andrzej Grzybowski, M.D., Ph.D., MBA, is a Professor of Ophthalmology and Chair of Department of Ophthalmology, University of Warmia and Mazury, Olsztyn, Poland; Head of Institute for Research in Ophthalmology, Foundation for Ophthalmology Development, Poznan, Poland.

He is active in international scientific societies including Euretina (Co-opted Board member 2016-2018), Retina Society, AAO (International Fellow; member of the Global ONE Advisory Board and Museum of Vision’s Program Committee), EVER (Board member and chair of cataract section), ESCRS (curator of ESCRS Archive), and ISRS (member of the ISRS International Council), ISBCS, International Council of Ophthalmology (programme coordinator for WCO in 2011-2018), and Cogan Society. He became lifelong member (chair LIV) of the European Academy of Ophthalmology and its Treasurer. He has been active contributor to major ophthalmic conferences worldwide, including AAO (Achievement Award 2017, International Scholar Award 2018), APAO (International Coordinator 2017, Achievement Award 2018), WCO (Programme Coordinator 2010-2018), Euretina, ESCRS, EVER, ISOPT, etc.

He has been active editor, editor in chief and author of more than 450 peer-reviewed international publications (total IF higher than 1000), and over 50 book’s chapters; reviewer for more than 20 journals. He is a member of editorial boards of American Journal of Ophthalmology (IF 4.795), Acta Ophthalmologica (IF 3.157), PLOS One (IF 2.806), Graefe’s Archive for Clinical and Experimental Ophthalmology (IF 2,349), Translational Vision Science & Technology (TVST), (IF 2.221), BMC Ophthalmology (IF 1.586), Clinics in Dermatology (IF 2.253), Journal of Clinical Medicine (IF 5.8); Frontiers in Neurology (IF 3.5), Neuro-Ophthalmology (IF 0.2), Saudi Journal of Ophthalmology, Asia Pacific Academy of Ophthalmology Journal, and editor in chief of Archives of History and Philosophy of Medicine and Historia Ophthalmologica Internationalis.

Piero Barboni, MD, graduated in Medicine and Surgery from the University of Bologna, Italy, in 1986 and went on to complete his Specialization in Ophthalmology at the same university in 1990. After spending almost two decades in private practice, he was appointed Professor of Neuro-ophthalmology in the Department of Neurological Science, Bologna University. Since 2012 Dr. Barboni has been a Consultant Ophthalmologist at the Scientific Institute San Raffaele, University of Milan. His memberships include the Association for Research in Vision and Ophthalmology (ARVO) and the North American Neuro-Ophthalmology Society (NANOS). Dr. Barboni has been sub-investigator in many clinical trials on good clinical practice in multiple sclerosis and is a participant in an international research project on Leber’s hereditary optic neuropathy. He is the author of more than 70 articles in peer-reviewed journals.   

Bibliographic information

  • Book Title OCT and Imaging in Central Nervous System Diseases
  • Book Subtitle The Eye as a Window to the Brain
  • Editors Andrzej Grzybowski
    Piero Barboni
  • DOI
  • Copyright Information Springer Nature Switzerland AG 2020
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-030-26268-6
  • Softcover ISBN 978-3-030-26271-6
  • eBook ISBN 978-3-030-26269-3
  • Edition Number 2
  • Number of Pages X, 561
  • Number of Illustrations 18 b/w illustrations, 141 illustrations in colour
  • Topics Ophthalmology
    Imaging / Radiology
  • Buy this book on publisher's site