Insulin Resistance

Childhood Precursors of Adult Disease

  • Philip S. Zeitler
  • Kristen J. Nadeau

Part of the Contemporary Endocrinology book series (COE)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Definition and Epidemiology

    1. Front Matter
      Pages 1-1
    2. Melinda E. Chen, Tamara S. Hannon
      Pages 3-17
    3. Sara Fleet Michaliszyn, Silva Arslanian
      Pages 19-35
    4. Uri Hamiel, Orit Pinhas-Hamiel
      Pages 37-51
  3. Pathophysiology

    1. Front Matter
      Pages 53-53
    2. Boris Draznin
      Pages 55-66
    3. Teri L. Hernandez, Jacob E. Friedman, Linda A. Barbour
      Pages 67-94
    4. Jill Landsbaugh Kaar, Dana Dabelea
      Pages 95-108
    5. David B. Dunger, Burak Salgin, Ken K. Ong
      Pages 109-117
    6. Jennifer E. Sprague, Rachelle Gandica, Megan Moriarty Kelsey
      Pages 119-131
    7. Shanlee M. Davis, Vanessa D. Sherk, Janine Higgins
      Pages 133-153
    8. Giuseppina Rosaria Umano, Sonia Caprio
      Pages 155-167
    9. Kimberly A. Cox-York, Rocio I. Pereira
      Pages 169-193
    10. Jessica E. Haley, Elaine M. Urbina
      Pages 195-205
    11. Charissa Y. Chang, Kerry Whitt, Zhenqi Liu, Stephen H. Caldwell
      Pages 207-219
    12. Petter Bjornstad, David Z. Cherney
      Pages 221-235
  4. Unique Models of Insulin Resistance in Youth

    1. Front Matter
      Pages 237-237
    2. Sara E. Pinney, Rebecca A. Simmons
      Pages 239-253
    3. Anne-Marie Carreau, Marie-Hélène Pesant, Jean-Patrice Baillargeon
      Pages 255-274
  5. Treatment

    1. Front Matter
      Pages 275-275
    2. Thomas Reinehr
      Pages 277-291
    3. Irene E. Schauer, Judith G. Regensteiner, Jane E. B. Reusch
      Pages 293-323
    4. Linda L. Buckley, Daniel H. Bessesen, Philip S. Zeitler
      Pages 325-333
  6. Back Matter
    Pages 347-356

About this book


Now in a revised and expanded second edition, this unique text presents topics related to insulin resistance in youth and its consequences across the lifespan. In the first section of the book examining epidemiology, the contributors review controversies over the definition of insulin resistance in children and what is known about how insulin resistance in youth differs from adults, the measurement of insulin resistance in youth in the research and clinical settings, and current knowledge regarding the epidemiology of insulin resistance in the pediatric population. The second section of the book explores pathophysiology, including current knowledge of the molecular, metabolic, and physiologic mechanisms of insulin resistance, the unique pathophysiology of pregnancy and puberty, the contributions of the prenatal and early childhood environment to the development of insulin resistance, and adipose and biochemical mediators. This section concludes with discussion of the relationship between insulin resistance and cardiovascular disease and liver disorders.  A third section, new to this second edition, explores insulin resistance in unique models: intrauterine growth restriction and girls with polycystic ovary syndrome and metabolic syndrome. The final section of the book explores the concepts of treatment through medications directed at insulin sensitivity, as well as exercise, weight loss medications and consequences of bariatric surgery.

Insulin Resistance: Childhood Precursors of Adult Disease, Second Edition provides up-to-date reviews of all of these areas, providing the reader with a current perspective on issues in insulin resistance in youth, an emerging risk factor for disease across the lifespan, that will spur continued interest in the topic on the part of clinicians and researchers, perhaps promoting new points of view and creative approaches to this daunting challenge.


Adiposity Bariatric surgery Biomarkers Body composition Ectopic fat distribution Exercise Insulin resistance Intrauterine growth restriction Metabolic syndrome Metabolism Molecular mechanisms Obesity Polycystic ovary syndrome Type 1 diabetes Type 2 diabetes Weight loss

Editors and affiliations

  • Philip S. Zeitler
    • 1
  • Kristen J. Nadeau
    • 2
  1. 1.Section of Pediatric EndocrinologyChildren’s Hospital ColoradoAuroraUSA
  2. 2.Department of PediatricsChildren’s Hospital ColoradoAuroraUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Switzerland AG 2020
  • Publisher Name Humana, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-030-25055-3
  • Online ISBN 978-3-030-25057-7
  • Series Print ISSN 2523-3785
  • Series Online ISSN 2523-3793
  • Buy this book on publisher's site