Central Nervous System Metastases

  • Manmeet Ahluwalia
  • Philippe Metellus
  • Riccardo Soffietti

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Epidemiology, Pathology and Molecular Biology

    1. Front Matter
      Pages 1-1
    2. Linda Dirven, Martin J. B. Taphoorn
      Pages 3-14
    3. Dana A. Mustafa, Rute Pedrosa, Johan M. Kros
      Pages 15-29
    4. Ekrem Emrah Er, Adrienne Boire
      Pages 31-41
    5. Franziska M. Ippen, Elisa Aquilanti, Helen D’Couto, Julia Grosch, Priscilla K. Brastianos
      Pages 43-58
    6. Pedro García-Gómez, Neibla Priego, Laura Álvaro-Espinosa, Manuel Valiente
      Pages 59-71
    7. Mafalda Antunes Ferreira, Silvia D’Ambrosi, Thomas Würdinger, Pieter Wesseling, Danijela Koppers-Lalic
      Pages 73-86
    8. Alex Wu, Anurag N. Paranjape, Brunilde Gril
      Pages 87-105
  3. Clinical/Radiological Presentation and Management

    1. Front Matter
      Pages 107-107
    2. Annette Compter, Dieta Brandsma
      Pages 109-115
    3. Roberta Rudà, Alessia Pellerino, Riccardo Soffietti
      Pages 117-125
    4. Fabian Wolpert, Patrick Roth
      Pages 127-137
    5. Christine Marosi, Cihan Ay
      Pages 139-143
    6. Gabriel C. T. E. Garcia, Sophie Bockel, Michaël Majer, Samy Ammari, Marion Smits
      Pages 145-158
    7. Norbert Galldiks, Bogdana Suchorska, Nathalie L. Albert, Jörg C. Tonn
      Pages 159-171
  4. Surgery, Radiation Therapy and Systemic Treatments

    1. Front Matter
      Pages 181-181
    2. Philippe Metellus, Johan Pallud, Zvi Ram, Colin Watts, Manfred Westphal
      Pages 183-190
    3. Ali S. Haider, Raymond Sawaya, Sherise D. Ferguson
      Pages 191-198
    4. Christophe Marques, Eric L. Chang
      Pages 199-238
    5. Frédéric Dhermain
      Pages 239-245
    6. Andrew Dhawan, Manmeet Ahluwalia
      Pages 259-266
    7. Rupert Bartsch, Elisabeth Sophie Bergen, Karin Dieckmann, Anna Sophie Berghoff, Matthias Preusser
      Pages 267-279
    8. C. Boutros, C. Robert
      Pages 281-287
    9. Andrew Dhawan, David Peereboom
      Pages 289-299
    10. Emilie Le Rhun, Michael Weller
      Pages 301-311
  5. Toxicity from Treatments

    1. Front Matter
      Pages 313-313
    2. Karine A. Al Feghali, Caroline Chung, Jeffrey S. Wefel, Mariana E. Bradshaw
      Pages 315-328
    3. Maria Diaz, David Schiff
      Pages 329-340
    4. Ugonma N. Chukwueke, Eudocia Q. Lee, Patrick Y. Wen
      Pages 341-363
    5. Ugonma N. Chukwueke, Eudocia Q. Lee, Patrick Y. Wen
      Pages 365-372
  6. Prognostic Classifications and Future Trial Design

    1. Front Matter
      Pages 383-383
    2. Riccardo Soffietti, Alessia Pellerino, Roberta Rudà
      Pages 397-406

About this book


This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives.

Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach.

Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.


Brain tumor Cancer and metastatic disease Chemotherapy, targeted therapy and immunotherapy Radiation therapy Neurosurgery

Editors and affiliations

  • Manmeet Ahluwalia
    • 1
  • Philippe Metellus
    • 2
  • Riccardo Soffietti
    • 3
  1. 1.Brain Tumor and Neuro-Oncology CenterCleveland ClinicClevelandUSA
  2. 2.Department of Neurosurgery and Neuro-Oncology, Clairval Hospital Center, Ramsay-Générale de Santé, Marseille, France, Neurophysiopathology InstituteAix-Marseille UniversitéMarseilleFrance
  3. 3.Department of Neuro-OncologyUniversity and City of Health and Science HospitalTurinItaly

Bibliographic information