Diminished Ovarian Reserve and Assisted Reproductive Technologies

Current Research and Clinical Management

  • OrhanĀ Bukulmez

Table of contents

  1. Front Matter
    Pages i-xx
  2. The Paradigm of Diminished Ovarian Reserve, Conventional & Adjuvant Treatment Approaches for Assisted Reproductive Technologies

  3. Minimal and Mild Stimulation Protocols

  4. Utilization of Contemporary Technologies in Diminished Ovarian Reserve Patients

    1. Front Matter
      Pages 277-277
    2. Zexu Jiao
      Pages 279-287
  5. Future Prospects

    1. Front Matter
      Pages 299-299
    2. Orhan Bukulmez
      Pages 315-327
    3. Rachel M. Whynott, Hakan E. Duran
      Pages 329-338
  6. Back Matter
    Pages 353-360

About this book


This book brings together the most current research and the latest clinical approaches to the management of diminished ovarian reserve (DOR), one of the largest segments of the IVF patient population, both in the advanced reproductive age group as well as poor responders. Opening with a review of the definition and scope of the problem, as well as the current understanding of the natural history of DOR, subsequent chapters in part I outline dietary, hormonal, traditional supplements and conventional methods used to stimulate ovaries and improve ART outcomes. The main segment of chapters, comprising part II, present minimal and mild stimulation protocols and alternatives, frozen embryo transfer preparation, trigger agents and post-trigger testing, embryo culture and endometrial considerations, and a review of clinical outcomes. Part III discusses the utilization of contemporary technologies in the treatment of DOR, including fresh vs. frozen embryo transfer, cryopreservation and comprehensive chromosomal analysis. Future prospects are presented in part IV, such as the artificial oocyte and ovary development, early-age oocyte freezing, ovarian cortical tissue freezing and activation of the ovarian cortex.

Utilizing the latest evidence and authored by an international array of thought leaders, Diminished Ovarian Reserve and Assisted Reproductive Technologies is an excellent resource for reproductive medicine and REI specialists, IVF lab professionals, and students and residents in these areas.


Assisted reproductive technologies (ART) Chromosome analysis Diminished ovarian reserve (DOR) Embryo cryopreservation Embryo culture Embryo transfer Hormonal supplement In vitro fertilization (IVF) Mild stimulation protocol Natural cycle approach Ovarian aging Ovarian stimulation protocol Premature ovarian insufficiency Premature ovulation Trigger agent

Editors and affiliations

  • OrhanĀ Bukulmez
    • 1
  1. 1.Division of Reproductive Endocrinology and Infertility Department of Obstetrics and GynecologyThe University of Texas Southwestern Medical CenterDallasUSA

Bibliographic information