Advertisement

The Golgi Apparatus and Centriole

Functions, Interactions and Role in Disease

  • Malgorzata Kloc

Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 67)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Golgi and Centriole Structure, Assembly and Regulation

    1. Front Matter
      Pages 1-1
    2. Delowar Hossain, William Y. Tsang
      Pages 17-25
    3. John Copeland
      Pages 27-48
    4. Alexander A. Mironov, Ivan D. Dimov, Galina V. Beznoussenko
      Pages 49-79
    5. Malgorzata Kloc, Ahmed Uosef, Jarek Wosik, Jacek Z. Kubiak, Rafik Mark Ghobrial
      Pages 81-93
    6. Cinzia Progida
      Pages 95-123
  3. Golgi and Centriole Positioning, Interactions and Dynamics

    1. Front Matter
      Pages 125-125
    2. Angel-Carlos Roman, Sergio Garrido-Jimenez, Selene Diaz-Chamorro, Francisco Centeno, Jose Maria Carvajal-Gonzalez
      Pages 201-221
    3. Meritxell Roig-Martinez, Elena Saavedra-Lopez, Paola V. Casanova, George P. Cribaro, Carlos Barcia
      Pages 223-231
  4. Role of Centriole and Golgi in the Organization of Cell, Embryo and Organ Geometry

  5. Golgi- and Centriole-Related Diseases

    1. Front Matter
      Pages 389-389
    2. Arunabha Bose, Sorab N. Dalal
      Pages 413-440
    3. Jie Li, Erpan Ahat, Yanzhuang Wang
      Pages 441-485

About this book

Introduction

This volume takes a closer look how the cell organelles Golgi apparatus (also known as the Golgi complex or Golgi body), and centriole are structurally and functionally intertwined.

Initially, it was believed that the role of Golgi complex is limited to the packaging and preparation for secretion of various cellular proteins, while the centriole participates in cell division and cilia formation. However, since their discovery nearly 200 years ago, it became clear that these two organelles are interacting, and that their functions are much more complex and far reaching than previously thought. Recent findings indicate that the Golgi–Centriole relationship may be important for directional protein transport, cell polarization and cell cycle progression. Current studies indicate that Golgi and centriole also participate in development and act as cellular and immunological sensors, and that their abnormalities lead to cell and developmental abnormalities, Alzheimer, cancer, various lipid disorders and neurological and immunological diseases in humans. 

This volume combines the latest information on the structure, molecular composition, and roles of Golgi and centriole in various cellular functions and diseases. The better understanding of the Golgi–centriole interactions may lead to the development of novel therapies for the treatment of various diseases, including cancer.

 

Keywords

Golgi apparatus Centriole golgi complex Golgi body Cell organelles dictyosome endoplasmic reticulum endomembrane system eukaryotic cells cellular organelles

Editors and affiliations

  • Malgorzata Kloc
    • 1
  1. 1.Department of SurgeryHouston Methodist HospitalHoustonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-030-23173-6
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-030-23172-9
  • Online ISBN 978-3-030-23173-6
  • Series Print ISSN 0080-1844
  • Series Online ISSN 1861-0412
  • Buy this book on publisher's site