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Human Epigenetics: How Science Works

  • Carsten Carlberg
  • Ferdinand Molnár

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Carsten Carlberg, Ferdinand Molnár
    Pages 1-13
  3. Carsten Carlberg, Ferdinand Molnár
    Pages 15-28
  4. Carsten Carlberg, Ferdinand Molnár
    Pages 29-39
  5. Carsten Carlberg, Ferdinand Molnár
    Pages 41-49
  6. Carsten Carlberg, Ferdinand Molnár
    Pages 51-62
  7. Carsten Carlberg, Ferdinand Molnár
    Pages 63-73
  8. Carsten Carlberg, Ferdinand Molnár
    Pages 75-87
  9. Carsten Carlberg, Ferdinand Molnár
    Pages 89-99
  10. Carsten Carlberg, Ferdinand Molnár
    Pages 101-111
  11. Carsten Carlberg, Ferdinand Molnár
    Pages 113-122
  12. Carsten Carlberg, Ferdinand Molnár
    Pages 123-134
  13. Carsten Carlberg, Ferdinand Molnár
    Pages 135-144
  14. Back Matter
    Pages 145-153

About this book

Introduction

The view “It’s all in our genes and we cannot change it” developed in the past 150 years since Gregor Mendel’s experiments with flowering pea plants. However, there is a special form of genetics, referred to as epigenetics, which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes dynamically throughout our whole life. Thus, we have the chance to change our epigenetics in a positive as well as negative way and are able to prevent the onset of diseases, such a type 2 diabetes or cancer.

This book provides a molecular explanation how our genome is connected with environmental signals. It outlines that epigenetic programming is a learning process that results in epigenetic memory in each of the cells forming our body. The central importance of epigenetics during embryogenesis and cellular differentiation as well as in the process of aging and the risk for the development of cancer are discussed. Moreover, the role of the epigenome as a molecular storage of cellular events not only in the brain but also in metabolic organs and in the immune system is described.

The book represents an updated but simplified version of our textbook “Human Epigenomics” (ISBN 978-981-10-7614-8). The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease.

Keywords

Genetics Inheritance Chromatin Molecular medicine Cell nucleus

Authors and affiliations

  • Carsten Carlberg
    • 1
  • Ferdinand Molnár
    • 2
  1. 1.Institute of BiomedicineUniversity of Eastern FinlandKuopioFinland
  2. 2.Department of BiologyNazarbayev UniversityNur-SultanKazakhstan

Bibliographic information