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Bile Acids and Their Receptors

  • Stefano Fiorucci
  • Eleonora Distrutti

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 256)

Table of contents

  1. Front Matter
    Pages i-x
  2. Stefano Fiorucci, Eleonora Distrutti
    Pages 3-18
  3. Verena Keitel, Jan Stindt, Dieter Häussinger
    Pages 19-49
  4. Marica Cariello, Marilidia Piglionica, Raffaella Maria Gadaleta, Antonio Moschetta
    Pages 73-93
  5. Francesco Saverio Di Leva, Daniele Di Marino, Vittorio Limongelli
    Pages 111-136
  6. Simona De Marino, Carmen Festa, Valentina Sepe, Angela Zampella
    Pages 137-165
  7. Christian Gege, Eva Hambruch, Nina Hambruch, Olaf Kinzel, Claus Kremoser
    Pages 167-205
  8. Tim van Zutphen, Anna Bertolini, Hilde D. de Vries, Vincent W. Bloks, Jan Freark de Boer, Johan W. Jonker et al.
    Pages 207-234
  9. Stefano Fiorucci, Eleonora Distrutti
    Pages 265-282
  10. Stefano Fiorucci, Cristina Di Giorgio, Eleonora Distrutti
    Pages 283-295
  11. Verena Keitel, Carola Dröge, Dieter Häussinger
    Pages 299-324
  12. Lili Ding, Zhipeng Fang, Yanjun Liu, Eryun Zhang, Tracy Huang, Li Yang et al.
    Pages 359-378

About this book

Introduction

This book focusses on the latest results related to the field of  bile acids as signaling molecules  and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas of metabolism. While FXR  and GPBAR1 are essential bile acid sensors that  integrate the de novo bile acid synthesis with intestinal microbiota and  liver metabolism, in a broader sense,  BARs  play a pathogenic role in the development of common human alignments  including  liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis. 

Keywords

Bile acids Nuclear receptors G protein coupled receptors Liver steato-hepatitis (NASH) Lipid metabolism Glucose metabolism

Editors and affiliations

  • Stefano Fiorucci
    • 1
  • Eleonora Distrutti
    • 2
  1. 1.University of Perugia, School of MedicinePerugiaItaly
  2. 2.S.C. Gastroenterologia, Azienda Ospedaliera di PerugiaPerugiaItaly

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-030-22005-1
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-030-22004-4
  • Online ISBN 978-3-030-22005-1
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site