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Pharmacology of Immunotherapeutic Drugs

  • Clinton B. Mathias
  • Jeremy P. McAleer
  • Doreen E. Szollosi
Textbook

Table of contents

  1. Front Matter
    Pages i-xix
  2. Doreen E. Szollosi, Clinton B. Mathias
    Pages 43-66
  3. Doreen E. Szollosi, Clinton B. Mathias, Jeremy P. McAleer
    Pages 67-98
  4. Clinton B. Mathias, Jeremy P. McAleer, Doreen E. Szollosi
    Pages 175-205
  5. Doreen E. Szollosi, Kirsten Hokeness, Mohammed K. Manzoor
    Pages 207-249
  6. Clinton B. Mathias, Jeremy P. McAleer
    Pages 251-276
  7. Doreen E. Szollosi, Clinton B. Mathias, Victoria Lucero, Sunna Ahmad, Jennifer Donato
    Pages 277-319
  8. Doreen E. Szollosi, Shannon R. M. Kinney, A. R. M. Ruhul Amin, Ngumbah Chumbow
    Pages 321-355
  9. Back Matter
    Pages 357-399

About this book

Introduction

Medicine has entered a golden age in which therapeutic agents are becoming widely available due to advances in basic science and technology. As such, many drugs have been developed that target inflammatory processes and/or the immune system. This book is intended for health professionals examining the modulation of inflammation by immunotherapeutic drugs. 

The immune system fills the primordial role of host defense and resistance to infections with pathogenic microorganisms. Several hematopoietic-derived cells constituting the innate and adaptive immune systems cooperate to provide barriers for microbial colonization and/or promote pathogen destruction within the host. Conversely, many immune cells are also involved in the pathogenesis and propagation of chronic inflammatory diseases. The beginning of this book details various components of the immune system including the cell types, lymphoid tissues, soluble cytokines and surface molecules that are essential for host defense. Breakdowns in immune tolerance, or dysregulated immune responses to antigens derived from self tissues or innocuous sources, can lead to the development of autoimmunity or chronic inflammatory diseases. Pathophysiologic roles for the immune system are detailed in corresponding chapters on autoimmunity, epithelial surfaces (lungs, skin, intestine), and transplantation, with special emphasis placed on immunotherapeutic drug targets. The last section of the book focuses on treatments that stimulate our immune system to specifically target and fight infectious diseases and cancer.  In each chapter, the medications used to treat various diseases/conditions in terms of their mechanism of action and other pharmacologic properties are discussed in detail. Chapters begin with a table showing drug names and classifications. The importance of basic science and clinical trials cannot be understated in the context of drug development.  As such, the discovery of certain medications that had a lasting impact in medicine and pharmacy are highlighted in chapter subsections named “Bench to Bedside.”  Several clinical applications of immunotherapeutic drugs are described within end-of -chapter case studies including practice questions. 

The Pharmacology of Immunotherapeutic Drugs is a reference for immunologists and clinicians (medical doctors, pharmacists, nurses) examining the modulation of inflammatory processes by a variety of medications targeting the cells and mediators of our immune system.​

Keywords

immunotherapy immune pharmacology immunopathogenesis immunomodulation biologics immunosuppression

Editors and affiliations

  • Clinton B. Mathias
    • 1
  • Jeremy P. McAleer
    • 2
  • Doreen E. Szollosi
    • 3
  1. 1.Department of Pharmaceutical and Administrative Sciences College of Pharmacy and Health SciencesWestern New England UniversitySpringfieldUSA
  2. 2.Pharmaceutical Science and Research School of PharmacyMarshall UniversityHuntingtonUSA
  3. 3.Department of Pharmaceutical Sciences School of Pharmacy and Physician Assistant StudiesUniversity of Saint JosephHartfordUSA

Bibliographic information