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Efficacy Analysis in Clinical Trials an Update

Efficacy Analysis in an Era of Machine Learning

  • Ton J. Cleophas
  • Aeilko H. Zwinderman

Table of contents

  1. Front Matter
    Pages i-xi
  2. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 1-35
  3. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 37-53
  4. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 55-61
  5. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 63-73
  6. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 75-85
  7. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 87-94
  8. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 95-105
  9. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 107-118
  10. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 119-135
  11. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 137-146
  12. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 147-171
  13. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 173-184
  14. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 185-194
  15. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 195-210
  16. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 211-221
  17. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 223-236
  18. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 237-251
  19. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 253-267
  20. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 269-278
  21. Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 279-298
  22. Back Matter
    Pages 299-304

About this book

Introduction

Machine learning and big data is hot. It is, however, virtually unused in clinical trials. This is so, because randomization is applied to even out multiple variables.

Modern medical computer files often involve hundreds of variables like genes and other laboratory values, and computationally intensive methods are required.  

This is the first publication of clinical trials that have been systematically analyzed with machine learning. In addition, all of the machine learning analyses were tested against traditional analyses. Step by step statistics for self-assessments are included.

The authors conclude, that machine learning is often more informative, and provides better sensitivities of testing than traditional analytic methods do.

Keywords

Clinical trials Traditional efficacy analysis Machine learning for efficacy analysis Data mining Big data validation

Authors and affiliations

  • Ton J. Cleophas
    • 1
  • Aeilko H. Zwinderman
    • 2
  1. 1.Albert Schweitzer HospitalDepartment MedicineSliedrechtThe Netherlands
  2. 2.Dept. Biostatistics and EpidemiologyAcademic Medical CenterAmsterdamThe Netherlands

Bibliographic information