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© 2019

Thymus Transcriptome and Cell Biology

  • Geraldo A. Passos
Book

Table of contents

  1. Front Matter
    Pages i-xvii
    PDF
  2. History of the Thymus: From a Vestigial Organ to the Programming of Immunological Self-Tolerance
    Vincent Geenen, Wilson Savino
    Pages 1-18
  3. Thymus Ontogeny and Development
    J. J. Muñoz, A. G. Zapata
    Pages 19-34
  4. The Ins and Outs of Thymic Epithelial Cell Differentiation and Function
    Minoru Matsumoto, Pedro M. Rodrigues, Laura Sousa, Koichi Tsuneyama, Mitsuru Matsumoto, Nuno L. Alves
    Pages 35-65
  5. T-Cell Development: From T-Lineage Specification to Intrathymic Maturation
    Kogulan Yoganathan, Edward L. Y. Chen, Jastaranpreet Singh, Juan Carlos Zúñiga-Pflücker
    Pages 67-115
  6. Intrathymic Cell Migration: Implications in Thymocyte Development and T-Cell Repertoire Formation
    Daniella Arêas Mendes-da-Cruz, Carolina Valença Messias, Julia Pereira Lemos, Wilson Savino
    Pages 117-148
  7. Thymic Crosstalk: An Overview of the Complex Cellular Interactions That Control the Establishment of T-Cell Tolerance
    Magali Irla
    Pages 149-167
  8. The Autoimmune Regulator (AIRE) Gene, the Master Activator of Self-Antigen Expression in the Thymus
    Matthieu Giraud, Pärt Peterson
    Pages 169-189
  9. Aire Mutations and Autoimmune Diseases
    Anette S. B. Wolff, Bergithe E. Oftedal
    Pages 191-214
  10. The Thymus as a Mirror of the Body’s Gene Expression
    Geraldo A. Passos, Adriana B. Genari, Amanda F. Assis, Ana C. Monteleone-Cassiano, Eduardo A. Donadi, Ernna H. Oliveira et al.
    Pages 215-234
  11. Functional Genomics of the Infant Human Thymus: AIRE and Minipuberty
    Carlos Alberto Moreira-Filho, Silvia Yumi Bando, Fernanda Bernardi Bertonha, Magda Carneiro-Sampaio
    Pages 235-245
  12. Thymus Transcriptome of TGF-β Superfamily
    Arnon Dias Jurberg, Vinicius Cotta-de-Almeida
    Pages 247-254
  13. Development of Thymic Regulatory T Lymphocytes
    Larissa Vasconcelos-Fontes, Rafaella Ferreira-Reis, João Ramalho Ortigão-Farias, Arnon Dias Jurberg, Vinicius Cotta-de-Almeida
    Pages 255-272
  14. Adding Insult to Injury: Improving the Regenerative Capacity of the Aged Thymus Following Clinically Induced Damage
    Jarrod Dudakov, Michael L. Hun, Kahlia Wong, Georg Holländer, Ann P. Chidgey
    Pages 273-294
  15. Thymus Rejuvenation After Autologous Hematopoietic Stem Cell Transplantation in Patients with Autoimmune Diseases
    João R. Lima-Júnior, Lucas C. M. Arruda, Maria Carolina de Oliveira, Kelen C. R. Malmegrim
    Pages 295-309
  16. Back Matter
    Pages 311-318
    PDF

About this book

Introduction

This volume focuses on challenging field in biomedicine that is the genetic control of central immune tolerance. It covers the thymus development, their cellular components and their respective function, the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus, the Autoimmune regulator (Aire) gene, the mutations in this gene and manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity.

The thymus gland is a lymphoid organ implicated in the maturation, differentiation and selection of T cells. This organ is gained more and more attention in different biomedical research labs worldwide due to its function that is associated with the control of immune homeostasis in the body, establishing the central immune tolerance and preventing the onset of autoimmune diseases.

Keywords

Transcriptomics central immune tolerance, thymus gland autoimmunity Aire gene Crispr-Cas9.

Editors and affiliations

  • Geraldo A. Passos
    • 1
  1. 1.Laboratory of Genetics and Molecular Biology, Department of Basic and Oral Biology, School of Dentistry of Ribeirão PretoUniversity of São PauloRibeirão PretoBrazil

About the editors

Geraldo Aleixo Passos received his PhD degree in biochemistry (1988) from Ribeirão Preto Medical School, University of São Paulo, USP, Brazil. His postdoctoral studies were conducted at the Molecular Genetics Institute of Montpellier (CNRS), France (1992-94) with sequencing and physical mapping of the human immunoglobulin lambda locus on chromosome 22q11.2. During several years he worked in close collaboration in the microarray laboratory at Centre d´Immunologie de Marseille-Luminy (CIML, Marseille, France) (1999-2001) and then in the Unité INSERM 1090 in Marseille (2002-17) to study the large-scale gene expression in the thymus.  He is currently Associate Professor (Genetics and Molecular Biology) at School of Dentistry and Ribeirão Preto Medical School (USP, Campus of Ribeirão Preto, Brazil). He is the coordinator of the Molecular Immunogenetics Group. He was the adviser of two PhD theses awarded by Ministry of Education/CAPES: in 2008, one of his students received the CAPES Thesis Award and in 2010, another student received the distinction CAPES Thesis Honor in Genetics.

Bibliographic information