Molecular and Cell Biology of Cancer

When Cells Break the Rules and Hijack Their Own Planet

  • Rita Fior
  • Rita Zilhão

Part of the Learning Materials in Biosciences book series (LMB)

Table of contents

  1. Front Matter
    Pages I-IX
  2. Lília Perfeito
    Pages 21-30
  3. João T. Barata, Mariana L. Oliveira
    Pages 31-49
  4. Irina S. Fonseca, Mónica Bettencourt-Dias
    Pages 51-74
  5. Ana Rita Carlos
    Pages 75-96
  6. Inês Pimenta de Castro
    Pages 97-116
  7. Vanda Póvoa, Rita Fior
    Pages 117-139
  8. Ana Magalhães, Sergio Dias
    Pages 141-157

About this book


This textbook takes you on a journey to the basic concepts of cancer biology. It combines developmental, evolutionary and cell biology perspectives, to then wrap-up with an integrated clinical approach.

The book starts with an introductory chapter, looking at cancer in a nut shell. The subsequent chapters are detailed and the idea of cancer as a mass of somatic cells undergoing a micro-evolutionary Darwinian process is explored. Further, the main Hanahan and Weinberg “Hallmarks of Cancer” are revisited.  In most chapters, the fundamental experiments that led to key concepts, connecting basic biology and biomedicine are highlighted. In the book’s closing section all of these concepts are integrated in clinical studies, where molecular diagnosis as well as the various classical and modern therapeutic strategies are addressed.

The book is written in an easy-to-read language, like a one-on-one conversation between the writer and the reader, without compromising the scientific accuracy. Therefore, this book is suited not only for advanced undergraduates and master students but also for patients or curious lay people looking for a further understanding of this shattering disease


Cancer Immune evasion Cancer metabolism Signaling Angiogenesis Evolution

Editors and affiliations

  • Rita Fior
    • 1
  • Rita Zilhão
    • 2
  1. 1.Champalimaud Centre for the UnknownChampalimaud FoundationLisbonPortugal
  2. 2.Faculdade de Ciências da Universidade de LisboaLisbonPortugal

Bibliographic information