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A Phenomenological Mathematical Modelling Framework for the Degradation of Bioresorbable Composites

  • Ismael Moreno-Gomez

Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xliii
  2. Ismael Moreno-Gomez
    Pages 1-6
  3. Ismael Moreno-Gomez
    Pages 7-23
  4. Ismael Moreno-Gomez
    Pages 25-88
  5. Ismael Moreno-Gomez
    Pages 267-272
  6. Back Matter
    Pages 273-325

About this book

Introduction

This book presents a generalised computational model for the degradation of resorbable composites, using analytic expressions to represent the interwoven phenomena present during degradation. It then combines this modelling framework with a comprehensive database of quantitative degradation data mined from existing literature and from novel experiments, to provide new insights into the interrelated factors controlling degradation.

Resorbable composites made of biodegradable polyesters and calcium-based ceramics have significant therapeutic potential as tissue engineering scaffolds, as temporary implants and as drug-loaded matrices for controlled release. However, their degradation is complex and the rate of resorption depends on multiple connected factors such as the shape and size of the device, polymer chemistry and molecular weight, particle phase, size, volume fraction, distribution and pH-dependent dissolution properties. Understanding and ultimately predicting the degradation of resorbable composites is of central importance if we are to fully unlock the promise of these materials.

Keywords

Phenomenological Modelling of Degradation Biodegradable Polymer-Ceramics Composites Tricalcium Phosphate/Hydroxyapatite/Calcium Carbonate Composites Poly(alpha-hydroxy-acids) Composites Degradation Mechanisms in Vivo

Authors and affiliations

  • Ismael Moreno-Gomez
    • 1
  1. 1.Department of Materials Science and MetallurgyUniversity of CambridgeCambridgeUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-030-04990-4
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-030-04989-8
  • Online ISBN 978-3-030-04990-4
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061
  • Buy this book on publisher's site