Chaperokine Activity of Heat Shock Proteins

  • Alexzander A. A. Asea
  • Punit Kaur

Part of the Heat Shock Proteins book series (HESP, volume 16)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Immunological and Inflammatory Responses

    1. Front Matter
      Pages 1-1
    2. Punit Kaur, Alexzander A. A. Asea
      Pages 3-22
    3. Michael Oglesbee, Mi Young Kim, Yaoling Shu, Sonia Longhi
      Pages 23-55
    4. Brice Nativel, Cynthia Planesse, Philippe Gasque, Christine Robert Da Silva, Olivier Meihac, Wildriss Viranaïcken
      Pages 57-80
    5. Hoorieh Soleimanjahi, Asghar Abdoli
      Pages 147-154
    6. Asmita Choudhury, Pranoti Mandrekar
      Pages 155-177
    7. Saurabh Pandey, Javeed Ahmad, Nasreen Zafar Ehtesham
      Pages 179-191
    8. Mahdieh Molanouri Shamsi, Zuhair Mohammad Hassan, Reza Gharakhanlou
      Pages 193-209
    9. Maxim Shevtsov, Gabriele Multhoff
      Pages 211-243
  3. Physiological Responses

    1. Front Matter
      Pages 245-245
    2. Amin Isanejad, Hamid Amini
      Pages 247-277
    3. Yasuaki Tamura, Akihiro Yoneda, Norio Takei, Kaori Sawada
      Pages 279-297
    4. Haiyan Chu, Li Jin, Jiucun Wang
      Pages 299-312
  4. Back Matter
    Pages 313-320

About this book


Chaperokine is a term that describes the unique function of extracellular heat shock protein (eHsp) as both chaperone and cytokine. The cellular consequence of binding and signaling of eHsp is the stimulation of a potent and long lasting immune response. eHsp induces a plethora of immune responses including the release of bioactive mediators such as cytokines, chemokines, nitric oxide, apotogenic mediators, stimulation of the innate and adaptive immune response, migration and maturation of dendritic cells (DC) and the enhancement of natural killer cell-mediated cellular cytotoxicity.

This edited book provides the most comprehensive review of contemporary knowledge of the chaperokine activity of heat shock proteins (HSP) in biology and medicine. Using an integrative approach to understanding the chaperokine activity of HSP, the contributors provide an overview of novel mechanisms, signal transduction pathways and a concise understanding of how the principles of the chaperokine activity of HSP has been harnessed for therapeutic gain.

Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present cutting-edge research activities and importantly, the future direction of chaperokine research. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychology, Human Physiology, Zoology, Botany, Biotechnology, Molecular Medicine, Infectious Disease, Pathology and Pharmaceutical Sciences, as well as for researchers involved in Drug Discovery.


Immunological and inflammatory responses Physiological responses Extracellular heat shock protein Chaperone Cytokine

Editors and affiliations

  • Alexzander A. A. Asea
    • 1
  • Punit Kaur
    • 2
  1. 1.Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer CenterUniversity of Toledo College of Medicine and Life SciencesToledoUSA
  2. 2.Department of Experimental Radiation OncologyMD Anderson Cancer CenterHoustonUSA

Bibliographic information