Progress in Human African Trypanosomiasis, Sleeping Sickness

  • Michel Dumas
  • Bernard Bouteille
  • Alain Buguet

Table of contents

  1. Front Matter
    Pages I-XIII
  2. F. R. Opperdoes
    Pages 53-80
  3. J. C. Breton, B. Bouteille
    Pages 81-104
  4. P. Vincendeau, M. O. Jauberteau-Marchan, S. Daulouède, Z. Ayed
    Pages 137-156
  5. K. Kristensson, M. Bentivoglio
    Pages 157-181
  6. M. W. Radomski, G. Brandenberger
    Pages 183-190
  7. M. Dumas, S. Bisser
    Pages 215-233
  8. G. Chauvière, J. Périé
    Pages 281-287
  9. B. Bouteille, M. Keita, B. Enanga, J. Mezui Me Ndong
    Pages 289-300
  10. P. de Raadt, J. Jannin
    Pages 315-333
  11. Back Matter
    Pages 335-346

About this book


Human African Trypaniosomiasis (HAT) or sleeping sickness is an old disease to be now considered as reemergent. HAT is endemic in 36 sub-Saharan African countries, in areas where tsetse flies are found. The public health importance of HAT is underestimated, but the disease causes severe social disruption in many rural areas. Along the past fifteen years, numerous studies were made, and now, the mechanisms involved in the disease pathogenesis and in the characteristics of sleep-wake disruption become to be better understood. But, since 50 years, when current drugs were introduced, problems regarding HAT chemotherapy have not been solved. Nevertheless, in-depth studies about trypanosome metabolism have permitted to discover new drug targets. Written by specialists who are very experienced in their respective fields, the contributions provide an indispensable tool for practitioners and scientists.


biology fields metabolism pathogenesis therapy

Editors and affiliations

  • Michel Dumas
    • 1
  • Bernard Bouteille
    • 1
  • Alain Buguet
    • 2
  1. 1.Faculté de Médecine Institut d’Épidemiologie Neurologique et de Neurologie TropicaleUniversité de LimogesLimogesFrance
  2. 2.Unité de Physiologie de la VigilanceCentre de Recherches du Service de Santé des Armées Émile PardéLa Tronche CedexFrance

Bibliographic information