Molecular Mechanisms of Angiogenesis

From Ontogenesis to Oncogenesis

  • Jean-Jacques Feige
  • Gilles Pagès
  • Fabrice Soncin

Table of contents

  1. Front Matter
    Pages i-xi
  2. Angiogenesis During Embryonic Development

    1. Front Matter
      Pages 1-1
    2. Anne Eichmann, Luc Pardanaud
      Pages 3-23
    3. Florence Tatin, Taija Makinen
      Pages 25-44
  3. The Physiological Angiogenic Signal: Cellular and Molecular Mechanisms

    1. Front Matter
      Pages 45-45
    2. Thierry Couffinhal, Pascale Dufourcq, Cécile Duplàa
      Pages 77-97
    3. Yves Audigier, Loïc van den Berghe, Bernard Masri
      Pages 121-148
    4. Valérie Pinet, Virginie Deleuze, Danièle Mathieu
      Pages 149-167
  4. Hypoxia, Ischemia and Angiogenesis

    1. Front Matter
      Pages 169-169
    2. Laurent Muller, Catherine Monnot, Stéphane Germain
      Pages 171-197
    3. Olivier Cuvillier
      Pages 199-217
    4. Gaëlle Laurent, Fatima Mechta-Grigoriou
      Pages 219-233
  5. Tumor Angiogenesis

    1. Front Matter
      Pages 265-265
    2. Rodrigo Leite de Oliveira, Massimiliano Mazzone
      Pages 267-282
    3. Jenny Paupert, Maureen Van De Velde, Frédéric Kridelka, Agnès Noël
      Pages 283-306
    4. Thomas Daubon, Andreas Bikfalvi
      Pages 307-324

About this book

Introduction

Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological conditions including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells,…) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable bloodproof neovessels.

This book reviews recent advances in our understanding of the molecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observations into the context of developmental, post-natal and pathological neovascularization.

The book was published under the auspices of the French Angiogenesis Society. Most contributors are prominent members of this Society or international researchers who have actively contributed to the Annual Meetings of the Society.

Keywords

Angiogenesis Blood vessel Cancer Embryonic development Endothelial cell Lymphatic vessel

Editors and affiliations

  • Jean-Jacques Feige
    • 1
  • Gilles Pagès
    • 2
  • Fabrice Soncin
    • 3
  1. 1.UMR 1036, Biologie du Cancer et de l’InfectionInstitut de Recherches en Technologies et Sciences pour le Vivant, Université Grenoble-AlpesGrenobleFrance
  2. 2.Institute for Research on Cancer and aging of Nice (IRCAN)University of Nice Sophia AntipolisNiceFrance
  3. 3.CNRS UMR8161, Institut Pasteur de LilleInstitut de Biologie de LilleLilleFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-2-8178-0466-8
  • Copyright Information Springer-Verlag France 2014
  • Publisher Name Springer, Paris
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-2-8178-0465-1
  • Online ISBN 978-2-8178-0466-8
  • About this book