Physiology and Physiopathology of Adipose Tissue

  • Jean-Philippe Bastard
  • Bruno Fève

Table of contents

  1. Front Matter
    Pages i-xix
  2. Adipose Tissue Development

    1. Front Matter
      Pages 1-1
    2. Tala Mohsen-Kanson, Brigitte Wdziekonski, Phi Villageois, Anne-Laure Hafner, Nadège Lay, Pauline Martin et al.
      Pages 3-16
    3. Carine Chavey, Sylviane Lagarrigue, Jean-Sébastien Annicotte, Lluis Fajas
      Pages 17-25
    4. Anne Bouloumié, Jean Galitzky
      Pages 27-38
    5. Louis Casteilla, Valérie Planat-Benard, Patrick Laharrague, Béatrice Cousin, Anne Lorsignol
      Pages 39-49
    6. Joan Tordjman
      Pages 67-75
  3. Adipose Tissue Metabolic Functions

    1. Front Matter
      Pages 77-77
    2. Mireille Cormont, Vincent Kaddai
      Pages 79-99
    3. Isabelle Dugail, Soizic Le Lay
      Pages 123-139
    4. Dominique Langin, Etienne Mouisel
      Pages 141-157
    5. Robert Barouki, Karine Clément
      Pages 159-167
  4. Endocrine Functions of Adipocyte

    1. Front Matter
      Pages 169-169
    2. Luc Pénicaud, Anne Lorsignol
      Pages 171-185
    3. Jean-Philippe Bastard, Camille Vatier, Bruno Fève
      Pages 187-200
    4. Isabelle Castan-laurell, Cédric Dray, Claude Knauf, Philippe Valet
      Pages 201-211
    5. Christian Carpéné, Jean-Sébastien Saulnier-Blache
      Pages 213-227
  5. Pathology of Adipose Tissue

    1. Front Matter
      Pages 229-229

About this book

Introduction

The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose tissue is now recognized as a real endocrine organ that produces hormones such as the leptin acting to regulate food intake and energy balance in the central nervous system, a finding that has completely revolutionized the paradigm of energy homeostasis. Other adipokines have now been described and these molecules are taking on increasing importance in physiology and pathophysiology. Moreover, numerous works have shown that in obesity, but also in cases of lipodystophy, adipose tissue was the site of a local low-grade inflammation that involves immune cells such as macrophages and certain populations of lymphocytes. This new information is an important step in the pathophysiology of both obesity and related metabolic and cardiovascular complications. Finally, it is a unique and original work focusing on adipose tissue, covering biology and pathology by investigating aspects of molecular and cellular biology, general, metabolic, genetic and genomic biochemistry.

Keywords

Adipocytes Adipokines Adipose tissue adipogenesis inflammation

Editors and affiliations

  • Jean-Philippe Bastard
    • 1
  • Bruno Fève
    • 2
  1. 1.ParisFrance
  2. 2.Hôpital Saint-AntoineParisFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-2-8178-0343-2
  • Copyright Information Springer-Verlag France 2013
  • Publisher Name Springer, Paris
  • eBook Packages Medicine
  • Print ISBN 978-2-8178-0342-5
  • Online ISBN 978-2-8178-0343-2
  • About this book