Breast Cancer

A Lobar Disease

  • Tibor Tot

Table of contents

  1. Front Matter
    Pages i-xii
  2. Tibor Tot
    Pages 1-17
  3. Chanel E. Smart, Peter T. Simpson, Ana Cristina Vargas, Sunil R. Lakhani
    Pages 53-66
  4. Susan M. Love, Dixie J. Mills
    Pages 67-77
  5. Maria P. Foschini, Vincenzo Eusebi
    Pages 79-85
  6. László K. Tabár, Peter B. Dean, Tibor Tot, Nadja Lindhe, Mats Ingvarsson, Amy Ming-Fang Yen
    Pages 87-152
  7. Dominique Amy
    Pages 153-162
  8. Back Matter
    Pages 211-216

About this book


The theory of the sick lobe states that breast carcinoma is a lobar disease developing most often within a single lobe, meaning that, at an early stage, breast carcinoma occupies a limited, anatomically well-defined portion of the breast. This theory unites observed patterns from the genetic, developmental and morphological perspectives, into an overall concept. Breast Cancer: A Lobar Disease, presents this hypothesis and its consequences. The body of evidence, pro and contra, generated in recent years is presented in this volume. The chapters, all authored by leading experts in their respective areas, gather evidence from the perspectives of epidemiology, genetics, radiology, anatomy, developmental biology, morphology, endoscopy, ultrasound and therapeutics to give the reader a full picture of recent developments regarding the sick lobe hypothesis. Tibor Tot, MD PhD is Head of the Pathology and Clinical Cytology Department at the Central Hospital of Falun, in Sweden; breast cancer expert of the National Board of Health and Welfare in Sweden; and regular Course Director of the breast pathology program, the official educational program for Swedish residents in clinical pathology, oncology, radiology and surgery.

Editors and affiliations

  • Tibor Tot
    • 1
  1. 1.Department of Pathology and Clinical CytFalun Central HospitalFalunSweden

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag London Limited 2011
  • Publisher Name Springer, London
  • eBook Packages Medicine
  • Print ISBN 978-1-84996-313-8
  • Online ISBN 978-1-84996-314-5
  • Buy this book on publisher's site