Vascular Complications in Human Disease

Mechanisms and Consequences

  • David Abraham
  • Michael Dashwood
  • Clive Handler
  • Gerry Coghlan

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Treatments for Pulmonary Vascular Disease

    1. Front Matter
      Pages 1-1
    2. Patrick Vallance
      Pages 9-13
    3. Peter H. Sugden, Angela Clerk
      Pages 14-45
    4. Rachel J. Davies, Nicholas W. Morrell
      Pages 46-59
  3. Model Systems

    1. Front Matter
      Pages 61-61
    2. Neeraj Dhaun, David J. Webb, Jane Goddard
      Pages 63-76
    3. Kristofer Rubin, Åsa Lidén, Tijs van Wieringen, Rolf K. Reed
      Pages 105-115
  4. Vascular Complications

    1. Front Matter
      Pages 117-117
    2. Daryll M. Baker, Christopher Denton
      Pages 119-127
  5. Surgical Approaches

    1. Front Matter
      Pages 137-137
    2. Janice C. S. Tsui, Daryll M. Baker
      Pages 139-149
    3. Jamie Y. Jeremy, Sarah J. George, Nilima Shukla, Marcella Wyatt, Jonathon Bloor, Andrew C. Newby et al.
      Pages 158-176
  6. Genetics, Gene Therapy, and Tissue Engineering

    1. Front Matter
      Pages 177-177
    2. Dimitri P. Mikhailidis
      Pages 179-186
    3. Petra Disterer, Eyman Osman, James S. Owen
      Pages 197-212
    4. Adrian H. Chester, Najma Latif, Magdi H. Yacoub, Patricia M. Taylor
      Pages 229-239
  7. Back Matter
    Pages 241-251

About this book


Vascular disease provides a clear example of the inherent and practical relationship between basic science and clinical medicine. Basic science underpins the rationale of treatment and potential future therapeutic approaches; problems in clinical management often direct new lines of laboratory research. Progress in treatment cannot continue without this close collaboration and this book has been designed to review this fascinating collaborative field of medical science.

As part of this evolving collaboration, Vascular Complications of Human Disease: Mechanisms and Consequences reviews the study, pathogenesis, management and treatment of some of the most common vascular diseases. The book includes discussions of approaches to gene therapy and aspects of regenerative medicine plus also physiology and pathogenesis, surgical and pharmacologic treatment, and complications.

Clinical specialists caring for patients with any form of vascular disease must clearly understand the basic scientific rationale for disease pathogenesis. This book presents a cohesive review of our current understanding of the most important areas of clinical science and medicine in vascular disease and identifies areas for research in the future. It will be a useful reference for basic and clinical scientists, and clinical specialists in vascular surgery, cardiology, angiology, neurology and any discipline in which the vascular system plays a fundamental part in the disease process.


Bypass Lipoprotein angiogenesis atherosclerosis gene therapy genetics heart high-density lipoprotein (HDL) inflammation muscle prevention surgery vascular disease

Editors and affiliations

  • David Abraham
    • 1
  • Michael Dashwood
    • 2
  • Clive Handler
    • 3
    • 4
  • Gerry Coghlan
    • 5
  1. 1.Royal Free and University College Medical SchoolLondonUK
  2. 2.Clinical BiochemistryRoyal Free and University College Hospital Medical SchoolLondonUK
  3. 3.The National Pulmonary Hypertension UnitRoyal Free HospitalLondon
  4. 4.Department of MedicineRoyal Free and University College Hospital Medical SchoolLondonUK
  5. 5.Royal Free HospitalLondonUK

Bibliographic information

  • DOI
  • Copyright Information Springer London 2008
  • Publisher Name Springer, London
  • eBook Packages Medicine
  • Print ISBN 978-1-84628-918-7
  • Online ISBN 978-1-84628-919-4
  • Buy this book on publisher's site