Enzyme Kinetics in Drug Metabolism

Fundamentals and Applications

  • Swati Nagar
  • Upendra A. Argikar
  • Donald J. Tweedie

Part of the Methods in Molecular Biology book series (MIMB, volume 1113)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Swati Nagar, Upendra A. Argikar, Donald J. Tweedie
    Pages 1-6
  3. Fundamentals of Enzyme Kinetics

    1. Front Matter
      Pages 7-7
    2. Eleanore Seibert, Timothy S. Tracy
      Pages 9-22
    3. Eleanore Seibert, Timothy S. Tracy
      Pages 23-35
    4. Barbara Ring, Steven A. Wrighton, Michael Mohutsky
      Pages 37-56
    5. Michael Mohutsky, Stephen D. Hall
      Pages 57-91
    6. Larry C. Wienkers, Brooke Rock
      Pages 93-118
    7. Nigel J. Waters, R. Scott Obach, Li Di
      Pages 119-145
  4. Kinetics of Drug Metabolizing Enzymes and Transporters

    1. Front Matter
      Pages 147-147
    2. John T. Barr, Kanika Choughule, Jeffrey P. Jones
      Pages 167-186
    3. Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Weiskircher-Hildebrandt, Ismael J. Hidalgo
      Pages 229-252
  5. Modeling Considerations

  6. Variability in Kinetics

    1. Front Matter
      Pages 335-335

About this book

Introduction

Drug metabolism and transport are very important facets within the discipline of pharmaceutical sciences, with  enzyme kinetic concepts utilized regularly in characterizing and modeling the disposition and elimination of drugs. Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications focuses on very practical aspects of applying kinetic principles to drug metabolizing enzymes and transporters. Divided into five convenient sections, topics include the fundamental principles of enzyme kinetics, the kinetics of oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for both drug metabolizing enzymes and transporters including novel systems biology approaches, understanding of variability both experimental and interindividual (pharmacogenomic), and case studies that provide real life examples of applying these principles. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics especially suitable for the novice, in some cases step-by-step, readily reproducible protocols, and insights to help with troubleshooting and avoiding known pitfalls with extensive cross referencing to assist in learning.

 

Authoritative and easily accessible, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications serves as a very practical teaching tool for novice, non-mathematically trained scientists interested in these fundamental concepts and as an aid for their supervisors in teaching these principles.   

Keywords

drug metabolism drug transporters enzyme kinetic models enzyme kinetics kinetic analysis transporter kinetics

Editors and affiliations

  • Swati Nagar
    • 1
  • Upendra A. Argikar
    • 2
  • Donald J. Tweedie
    • 3
  1. 1.Department of Pharmaceutical SciencesTemple University School of PharmacyPhiladelphiaUSA
  2. 2.Novartis Inst. for BioMedical ResearchCambridgeUSA
  3. 3.Drug MetabolismBoehringer IngelheimRidgefieldUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-62703-758-7
  • Copyright Information Springer Science+Business Media, LLC 2014
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-62703-757-0
  • Online ISBN 978-1-62703-758-7
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • About this book