Molecular Toxicology Protocols

  • Phouthone Keohavong
  • Stephen G. Grant

Part of the Methods in Molecular Biology book series (MIMB, volume 1105)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Toxicoproteomics

    1. Front Matter
      Pages 1-1
    2. Katie Partyka, Shuangshuang Wang, Ping Zhao, Brian Cao, Brian Haab
      Pages 3-15
  3. Toxicant-Induced Inflammation

  4. Gene Promoter Methylation

  5. Array Technologies

    1. Front Matter
      Pages 83-83
    2. Kaori Shintani-Ishida, Bao-Li Zhu, Hitoshi Maeda
      Pages 117-124
  6. Analysis of DNA Adducts

    1. Front Matter
      Pages 125-125
    2. David H. Phillips, Volker M. Arlt
      Pages 127-138
    3. Karen H. Dingley, Esther A. Ubick, John S. Vogel, Ted J. Ognibene, Michael A. Malfatti, Kristen Kulp et al.
      Pages 147-157
    4. Walter A. Deutsch, Vijay Hegde
      Pages 159-168
  7. Detection of Chromosomal and Genome-Wide Damage

    1. Front Matter
      Pages 169-169

About this book

Introduction

Molecular Toxicology Protocols, Second Edition aims to bring together a series of articles describing validated methods to elucidate specific molecular aspects of toxicology, the emphasis being on the application of molecular methods to genetic toxicology. The volume is divided into ten parts, roughly corresponding to the spectrum of biomarkers intermediate between exposure and disease outcomes as proposed in molecular epidemiology models. Subjects of these new chapters range from preparation of fluid specimens for analysis of cellular inflammatory responses to genotoxic insults to sensitive methods for proteomic analysis and aberrant DNA methylation patterns. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and easily accessible, Molecular Toxicology Protocols, Second Edition addresses not only the needs of molecular biologists and toxicologists, but also those of individuals interested in applying molecular methods to clinical applications, such as geneticists, pathologists, biochemists, and epidemiologists. 

Keywords

DNA adducts DNA methylation array technology gene mutation toxicoproteomics

Editors and affiliations

  • Phouthone Keohavong
    • 1
  • Stephen G. Grant
    • 2
  1. 1.Occupational HealthUniversity of Pittsburgh Dept. Environmental &PittsburghUSA
  2. 2.Dept. of Pharmaceutical SciencesNova Southeastern University College of PharmacyFort LauderdaleUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-62703-739-6
  • Copyright Information Springer Science+Business Media New York 2014
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-62703-738-9
  • Online ISBN 978-1-62703-739-6
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • About this book