Peroxisome Proliferator-Activated Receptors

Discovery and Recent Advances

  • Jihan A. Youssef
  • Mostafa Z. Badr

Table of contents

  1. Front Matter
    Pages i-ix
  2. Jihan A. Youssef, Mostafa Z. Badr
    Pages 1-3
  3. Jihan A. Youssef, Mostafa Z. Badr
    Pages 5-14
  4. Jihan A. Youssef, Mostafa Z. Badr
    Pages 15-23
  5. Jihan A. Youssef, Mostafa Z. Badr
    Pages 25-32
  6. Jihan A. Youssef, Mostafa Z. Badr
    Pages 33-69
  7. Jihan A. Youssef, Mostafa Z. Badr
    Pages 71-77
  8. Jihan A. Youssef, Mostafa Z. Badr
    Pages 79-83
  9. Jihan A. Youssef, Mostafa Z. Badr
    Pages 85-85
  10. Jihan A. Youssef, Mostafa Z. Badr
    Pages 87-90
  11. Jihan A. Youssef, Mostafa Z. Badr
    Pages 91-92
  12. Back Matter
    Pages 93-137

About this book

Introduction

All three peroxisome proliferator-activated receptor (PPAR) subtypes share a high degree of structural homology while exhibiting differences in function, tissue distribution, and ligand specificity. In Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances, the authors trace the history of PPAR discovery and detail the receptor structure and its posttranslational modifications. Furthermore, endogenous ligands as well as various classes of exogenous ligands, subtype-selective, dual and pan agonists as well as antagonists, are discussed. In addition, the tissue distribution and versatile functions of PPAR subtypes in major organs are described.

 

As PPARs play critical roles as regulators of numerous physiological as well as pathophysiological pathways, Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances aims to help researchers to develop safer and more effective PPAR modulators as therapeutic agents to treat a myriad of diseases and conditions.

Keywords

PPAR discovery PPARs Peroxisome Proliferator-Activated Receptors Peroxisome proliferation Posttranslational modifications Receptor structure

Authors and affiliations

  • Jihan A. Youssef
    • 1
  • Mostafa Z. Badr
    • 2
  1. 1.School of PharmacyUniversity of Missouri-Kansas CityKansas CityUSA
  2. 2.School of PharmacyUniversity of Missouri-Kansas CityKansas CityUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-62703-420-3
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-62703-419-7
  • Online ISBN 978-1-62703-420-3